A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's
ABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, fi...
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| Format: | Article |
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Wiley
2025-06-01
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| Series: | Annals of Clinical and Translational Neurology |
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| Online Access: | https://doi.org/10.1002/acn3.70057 |
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| author | Natalia E. Owen Zanna J. Voysey Jonathan A. Holbrook Maura Malpetti Clara Le Draoulec Lennart R. B. Spindler Anna O. G. Goodman Alpar S. Lazar Roger A. Barker |
| author_facet | Natalia E. Owen Zanna J. Voysey Jonathan A. Holbrook Maura Malpetti Clara Le Draoulec Lennart R. B. Spindler Anna O. G. Goodman Alpar S. Lazar Roger A. Barker |
| author_sort | Natalia E. Owen |
| collection | DOAJ |
| description | ABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct longitudinal dynamics in premanifest/transitional HD. Here, we report the corresponding results for serum glial fibrillary acidic protein and total tau, providing the first longitudinal and head‐to‐head study of these biomarkers in HD. Our findings do not support the utility of these analytes as prognostic biomarkers in premanifest and transitional HD. |
| format | Article |
| id | doaj-art-48eded7a692d4adaa442b0b7de8898bc |
| institution | OA Journals |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-48eded7a692d4adaa442b0b7de8898bc2025-08-20T02:07:09ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-06-011261296130110.1002/acn3.70057A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington'sNatalia E. Owen0Zanna J. Voysey1Jonathan A. Holbrook2Maura Malpetti3Clara Le Draoulec4Lennart R. B. Spindler5Anna O. G. Goodman6Alpar S. Lazar7Roger A. Barker8Department of Clinical Neurosciences, John van Geest Centre for Brain Repair University of Cambridge Cambridge UKDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair University of Cambridge Cambridge UKDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair University of Cambridge Cambridge UKDepartment of Clinical Neurosciences, Cambridge Centre for Frontotemporal Dementia and Related Disorders University of Cambridge Cambridge UKDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair University of Cambridge Cambridge UKDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair University of Cambridge Cambridge UKDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair University of Cambridge Cambridge UKFaculty of Medicine and Health Sciences University of East Anglia Norwich UKDepartment of Clinical Neurosciences, John van Geest Centre for Brain Repair University of Cambridge Cambridge UKABSTRACT There is a pressing need for blood biomarkers that can identify Huntington's disease (HD) gene carriers' proximity to manifest disease. We previously examined serial serum neurofilament light (NfL) concentrations in 21 premanifest HD gene carriers and 14 controls over 14 years, finding that NfL demonstrates high prognostic value and distinct longitudinal dynamics in premanifest/transitional HD. Here, we report the corresponding results for serum glial fibrillary acidic protein and total tau, providing the first longitudinal and head‐to‐head study of these biomarkers in HD. Our findings do not support the utility of these analytes as prognostic biomarkers in premanifest and transitional HD.https://doi.org/10.1002/acn3.70057blood‐based biomarkersglial fibrillary acidic proteinHuntington's diseaseprognostic biomarkerstau |
| spellingShingle | Natalia E. Owen Zanna J. Voysey Jonathan A. Holbrook Maura Malpetti Clara Le Draoulec Lennart R. B. Spindler Anna O. G. Goodman Alpar S. Lazar Roger A. Barker A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's Annals of Clinical and Translational Neurology blood‐based biomarkers glial fibrillary acidic protein Huntington's disease prognostic biomarkers tau |
| title | A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's |
| title_full | A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's |
| title_fullStr | A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's |
| title_full_unstemmed | A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's |
| title_short | A 14‐Year Study of Serum Glial Fibrillary Acidic Protein and Total Tau in Premanifest Huntington's |
| title_sort | 14 year study of serum glial fibrillary acidic protein and total tau in premanifest huntington s |
| topic | blood‐based biomarkers glial fibrillary acidic protein Huntington's disease prognostic biomarkers tau |
| url | https://doi.org/10.1002/acn3.70057 |
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