COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study)
The aim: To assess the effect of COMT G1947A genetic polymorphism (val158met) on the efficacy of spinal analgesia on day 1 after laparoscopic surgery for colorectal cancer.Material and methods. In a pilot study involving 100 patients with colorectal cancer, operated through laparoscopic access, usin...
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2019-12-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1827 |
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| author | Alexander L. Potapov Daria V. Zemskova Tatiana I. Ivanova Vera A. Khorokhorina Peter V. Shegay Sergey A. Ivanov Andrey D. Kaprin |
| author_facet | Alexander L. Potapov Daria V. Zemskova Tatiana I. Ivanova Vera A. Khorokhorina Peter V. Shegay Sergey A. Ivanov Andrey D. Kaprin |
| author_sort | Alexander L. Potapov |
| collection | DOAJ |
| description | The aim: To assess the effect of COMT G1947A genetic polymorphism (val158met) on the efficacy of spinal analgesia on day 1 after laparoscopic surgery for colorectal cancer.Material and methods. In a pilot study involving 100 patients with colorectal cancer, operated through laparoscopic access, using spinal analgesia (10.0–12.5 mg of bupivacaine + 200 mcg of morphine), the frequency of COMT gene G1947A (val158met) polymorphism, the intensity of pain on day 1 after surgery, the frequency and severity of nausea, vomiting, skin itching, the need for additional analgesia have been assessed.Results. The frequency distribution of alleles val/val (25%), val/met (45%) and met/met (30%) was consisted with Hardy-Weinberg equilibrium (χ2=0.96; P>0.05) and was not significantly different from the healthy donor group. In the groups of patients with various COMT alleles of val158met polymorphism, the studied parameters also did not differ significantly.Conclusion. Study did not find significant link between spinal analgesia efficacy on day 1 after laparoscopic surgery for colorectal cancer and COMT rs4680 G1947A (val158met) polymorphism. Further research to enhance the power of the study is warranted to reach the final conclusions. |
| format | Article |
| id | doaj-art-48ea008d20214b058d651dc046727ced |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-48ea008d20214b058d651dc046727ced2025-08-20T03:18:50ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102019-12-0115641010.15360/1813-9779-2019-6-4-101712COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study)Alexander L. Potapov0Daria V. Zemskova1Tatiana I. Ivanova2Vera A. Khorokhorina3Peter V. Shegay4Sergey A. Ivanov5Andrey D. Kaprin6A. F. Tsyba Medical Radiological Research Center, National Medical Radiological Research Center, Ministry of Health of RussiaA. F. Tsyba Medical Radiological Research Center, National Medical Radiological Research Center, Ministry of Health of RussiaA. F. Tsyba Medical Radiological Research Center, National Medical Radiological Research Center, Ministry of Health of RussiaA. F. Tsyba Medical Radiological Research Center, National Medical Radiological Research Center, Ministry of Health of RussiaA. F. Tsyba Medical Radiological Research Center, National Medical Radiological Research Center, Ministry of Health of RussiaA. F. Tsyba Medical Radiological Research Center, National Medical Radiological Research Center, Ministry of Health of RussiaA. F. Tsyba Medical Radiological Research Center, National Medical Radiological Research Center, Ministry of Health of RussiaThe aim: To assess the effect of COMT G1947A genetic polymorphism (val158met) on the efficacy of spinal analgesia on day 1 after laparoscopic surgery for colorectal cancer.Material and methods. In a pilot study involving 100 patients with colorectal cancer, operated through laparoscopic access, using spinal analgesia (10.0–12.5 mg of bupivacaine + 200 mcg of morphine), the frequency of COMT gene G1947A (val158met) polymorphism, the intensity of pain on day 1 after surgery, the frequency and severity of nausea, vomiting, skin itching, the need for additional analgesia have been assessed.Results. The frequency distribution of alleles val/val (25%), val/met (45%) and met/met (30%) was consisted with Hardy-Weinberg equilibrium (χ2=0.96; P>0.05) and was not significantly different from the healthy donor group. In the groups of patients with various COMT alleles of val158met polymorphism, the studied parameters also did not differ significantly.Conclusion. Study did not find significant link between spinal analgesia efficacy on day 1 after laparoscopic surgery for colorectal cancer and COMT rs4680 G1947A (val158met) polymorphism. Further research to enhance the power of the study is warranted to reach the final conclusions.https://www.reanimatology.com/rmt/article/view/1827surgerycolorectal cancerspinal analgesiacatechol-o-methyltransferase (comt)polymorphism |
| spellingShingle | Alexander L. Potapov Daria V. Zemskova Tatiana I. Ivanova Vera A. Khorokhorina Peter V. Shegay Sergey A. Ivanov Andrey D. Kaprin COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study) Общая реаниматология surgery colorectal cancer spinal analgesia catechol-o-methyltransferase (comt) polymorphism |
| title | COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study) |
| title_full | COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study) |
| title_fullStr | COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study) |
| title_full_unstemmed | COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study) |
| title_short | COMT val158met Polymorphism and Spinal Analgesia Efficacy of Laparoscopic Surgery for Colorectal Cancer (a Pilot Study) |
| title_sort | comt val158met polymorphism and spinal analgesia efficacy of laparoscopic surgery for colorectal cancer a pilot study |
| topic | surgery colorectal cancer spinal analgesia catechol-o-methyltransferase (comt) polymorphism |
| url | https://www.reanimatology.com/rmt/article/view/1827 |
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