Abnormal Liver Function in Predicting COVID-19 Patients’ Prognosis
Despite of the high prevalence of liver enzyme elevation in COVID-19 patients, its effect on predicting COVID-19 patients’ prognosis was still debatable. This evidence-based case report aims to evaluate the effect of abnormal liver function in the prognosis of COVID-19 patients. Literature searching...
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| Format: | Article |
| Language: | Indonesian |
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Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2022-03-01
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| Series: | Jurnal Penyakit Dalam Indonesia |
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| Online Access: | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/624/302 |
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| author | Sakinah Rahma Sari Juferdy Kurniawan |
| author_facet | Sakinah Rahma Sari Juferdy Kurniawan |
| author_sort | Sakinah Rahma Sari |
| collection | DOAJ |
| description | Despite of the high prevalence of liver enzyme elevation in COVID-19 patients, its effect on predicting COVID-19 patients’ prognosis was still debatable. This evidence-based case report aims to evaluate the effect of abnormal liver function in the prognosis of COVID-19 patients. Literature searching was performed on August 16-17 2021 using 3 databases: PubMed, Scopus, and Proquest. The articles selected by title/abstract screening, duplication elimination, and applying eligibility criteria were then appraised using Centre of Evidence Based Medicine (CEBM), University of Oxford. Some of the studies reported there were no significant difference in the prognosis of COVID-19 patient with and without abnormal liver function. However, most of the studies reported abnormal liver function as an independent poor prognosis predictor in COVID-19 patients. Based on the study with the highest level of evidence, the elevation of AST and ALT increase the risk of poor prognosis in COVID-19 patients [OR 2.98 (95% CI 2.35-3.77), p<0.0001) and OR 1.73 (95% CI 1.32-2.27, p<0.001)]. Based on the 34 studies appraised, we conclude that abnormal liver function will increase the risk of poor prognosis in COVID-19 patients. Thus, careful monitoring must be done in COVID-19 patients with abnormal liver function. |
| format | Article |
| id | doaj-art-48e7308d33b94eb6905796ecfdb53644 |
| institution | OA Journals |
| issn | 2406-8969 2549-0621 |
| language | Indonesian |
| publishDate | 2022-03-01 |
| publisher | Department of Internal Medicine, Faculty of Medicine Universitas Indonesia |
| record_format | Article |
| series | Jurnal Penyakit Dalam Indonesia |
| spelling | doaj-art-48e7308d33b94eb6905796ecfdb536442025-08-20T02:01:09ZindDepartment of Internal Medicine, Faculty of Medicine Universitas IndonesiaJurnal Penyakit Dalam Indonesia2406-89692549-06212022-03-01914252http://dx.doi.org/10.7454/jpdi.v9i1.624Abnormal Liver Function in Predicting COVID-19 Patients’ PrognosisSakinah Rahma Sari0Juferdy Kurniawan1Universitas IndonesiaDivisi Hepatobilier, Kelompok Studi Medis Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta IndonesiaDespite of the high prevalence of liver enzyme elevation in COVID-19 patients, its effect on predicting COVID-19 patients’ prognosis was still debatable. This evidence-based case report aims to evaluate the effect of abnormal liver function in the prognosis of COVID-19 patients. Literature searching was performed on August 16-17 2021 using 3 databases: PubMed, Scopus, and Proquest. The articles selected by title/abstract screening, duplication elimination, and applying eligibility criteria were then appraised using Centre of Evidence Based Medicine (CEBM), University of Oxford. Some of the studies reported there were no significant difference in the prognosis of COVID-19 patient with and without abnormal liver function. However, most of the studies reported abnormal liver function as an independent poor prognosis predictor in COVID-19 patients. Based on the study with the highest level of evidence, the elevation of AST and ALT increase the risk of poor prognosis in COVID-19 patients [OR 2.98 (95% CI 2.35-3.77), p<0.0001) and OR 1.73 (95% CI 1.32-2.27, p<0.001)]. Based on the 34 studies appraised, we conclude that abnormal liver function will increase the risk of poor prognosis in COVID-19 patients. Thus, careful monitoring must be done in COVID-19 patients with abnormal liver function.http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/624/302abnormal liver functioncovid-19prognosis |
| spellingShingle | Sakinah Rahma Sari Juferdy Kurniawan Abnormal Liver Function in Predicting COVID-19 Patients’ Prognosis Jurnal Penyakit Dalam Indonesia abnormal liver function covid-19 prognosis |
| title | Abnormal Liver Function in Predicting COVID-19 Patients’ Prognosis |
| title_full | Abnormal Liver Function in Predicting COVID-19 Patients’ Prognosis |
| title_fullStr | Abnormal Liver Function in Predicting COVID-19 Patients’ Prognosis |
| title_full_unstemmed | Abnormal Liver Function in Predicting COVID-19 Patients’ Prognosis |
| title_short | Abnormal Liver Function in Predicting COVID-19 Patients’ Prognosis |
| title_sort | abnormal liver function in predicting covid 19 patients prognosis |
| topic | abnormal liver function covid-19 prognosis |
| url | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/624/302 |
| work_keys_str_mv | AT sakinahrahmasari abnormalliverfunctioninpredictingcovid19patientsprognosis AT juferdykurniawan abnormalliverfunctioninpredictingcovid19patientsprognosis |