Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation

Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation

Lung transplantation (LTx) significantly improves outcomes for patients with end-stage respiratory failure. However, primary graft dysfunction (PGD) remains one of the most relevant hurdles. Although PGD is attributed to ischemia-reperfusion injury (IRI), immune responses, primarily T cell-mediated,...

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Bibliographic Details
Main Authors: Vitale Miceli, Pia Ferrigno, Claudio Centi, Claudia Carcione, Gioacchin Iannolo, Valentina Agnese, Giovanna Lo Iacono, Rosa Liotta, Pier Giulio Conaldi, Massimo Pinzani, Lavinia De Monte, Alessandro Bertani
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
Lung transplantation
Primary graft dysfunction
microRNA
Immune checkpoints
Ischemia-reperfusion injury
Prognostic biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025008953
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