Research progress on the comorbidity mechanism of hemorrhoids and obstructive defecation syndrome
Hemorrhoids are the most common benign disease of the anorectal region, with a high incidence and recurrence rate. Current research on the pathogenesis of hemorrhoids mainly focuses on non-genetic factors, and there is a lack of systematic research on genetic factors. A recent genome-wide associatio...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Colorectal & Anal Surgery
2022-08-01
|
| Series: | 结直肠肛门外科 |
| Subjects: | |
| Online Access: | https://jcas.gxmuyfy.cn/cn/wqll/paper.html?id=378&cateName=2022%E5%B9%B4%20%E7%AC%AC28%E5%8D%B7%20%E7%AC%AC4%E6%9C%9F |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Hemorrhoids are the most common benign disease of the anorectal region, with a high incidence and recurrence rate. Current research on the pathogenesis of hemorrhoids mainly focuses on non-genetic factors, and there is a lack of systematic research on genetic factors. A recent genome-wide association study has demonstrated for the first time that hemorrhoids are a partially hereditary disease and has identified related risk genes, revealing the potential comorbidity mechanism between hemorrhoids and obstructive defecation syndrome from a genetic perspective. Furthermore, previous studies have often regarded functional constipation as a risk factor for hemorrhoids, especially the type of constipation characterized by discoordination or evacuation disorders is more common in patients with hemorrhoids combined with functional constipation. Recent clinical studies by our team have also shown a significant correlation between obstructive defecation syndrome and the recurrence rate of hemorrhoids after surgery. This article reviews and summarizes the research progress on the comorbidity mechanism of hemorrhoids and obstructive defecation syndrome from the perspectives of non-genetic and genetic factors, aiming to provide new insights for the study, clinical diagnosis, and management of the pathogenesis of both diseases. |
|---|---|
| ISSN: | 1674-0491 |