Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease
Behçet’s disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gamma de...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/705831 |
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| author | Md. Samiul Hasan Lesley Ann Bergmeier Harry Petrushkin Farida Fortune |
| author_facet | Md. Samiul Hasan Lesley Ann Bergmeier Harry Petrushkin Farida Fortune |
| author_sort | Md. Samiul Hasan |
| collection | DOAJ |
| description | Behçet’s disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gamma delta (γδ) T cells are reported to have a role. γδ T cells are atypical T cells, which represent a small proportion of total lymphocytes. They have features of both innate and adaptive immunity and express characteristics of conventional T cells, natural killer cells, and myeloid antigen presenting cells. These unconventional T cells are found in the inflammatory BD lesions and have been suggested to be responsible for inducing and/or maintaining the proinflammatory environment characteristic of the disease. Over the last 20 years there has been much interest in the role of γδ T cells in BD. We review the literature and discuss the roles that γδ T cells may play in BD pathogenesis. |
| format | Article |
| id | doaj-art-48e03d3399a64fee97fb70a2f683163f |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-48e03d3399a64fee97fb70a2f683163f2025-08-20T03:36:47ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/705831705831Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s DiseaseMd. Samiul Hasan0Lesley Ann Bergmeier1Harry Petrushkin2Farida Fortune3Centre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Blizard Building, 4 Newark Street, London E1 2AT, UKCentre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Blizard Building, 4 Newark Street, London E1 2AT, UKCentre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Blizard Building, 4 Newark Street, London E1 2AT, UKCentre for Clinical and Diagnostic Oral Sciences, Institute of Dentistry, Queen Mary University of London, Blizard Building, 4 Newark Street, London E1 2AT, UKBehçet’s disease (BD) is a multisystem inflammatory disorder characterized by orogenital ulcerations, ocular manifestations, arthritis, and vasculitis. The disease follows a relapsing-remitting course and its pathogenesis is unknown. Genetic predisposition and immune-dysregulation involving gamma delta (γδ) T cells are reported to have a role. γδ T cells are atypical T cells, which represent a small proportion of total lymphocytes. They have features of both innate and adaptive immunity and express characteristics of conventional T cells, natural killer cells, and myeloid antigen presenting cells. These unconventional T cells are found in the inflammatory BD lesions and have been suggested to be responsible for inducing and/or maintaining the proinflammatory environment characteristic of the disease. Over the last 20 years there has been much interest in the role of γδ T cells in BD. We review the literature and discuss the roles that γδ T cells may play in BD pathogenesis.http://dx.doi.org/10.1155/2015/705831 |
| spellingShingle | Md. Samiul Hasan Lesley Ann Bergmeier Harry Petrushkin Farida Fortune Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease Journal of Immunology Research |
| title | Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease |
| title_full | Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease |
| title_fullStr | Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease |
| title_full_unstemmed | Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease |
| title_short | Gamma Delta (γδ) T Cells and Their Involvement in Behçet’s Disease |
| title_sort | gamma delta γδ t cells and their involvement in behcet s disease |
| url | http://dx.doi.org/10.1155/2015/705831 |
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