Intra-tumoral lymphocyte scoring in colorectal cancer: improving prognostic utility and correlation with underlying cancer biology

Intra-tumoral lymphocyte scoring in colorectal cancer: improving prognostic utility and correlation with underlying cancer biology

BackgroundIntra-tumoral lymphocytes hold prognostic and predictive significance in colorectal cancer (CRC). The internationally validated Immunoscore™ predicts CRC survival risk by averaging percentile scores of tumor-associated CD3+ and CD8+ cell densities, but is limited by increased cost, intra-t...

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Bibliographic Details
Main Authors: Patrick L. Wagner, Jianwu Xie, Devin C. Flaherty, Hyun Park, Chelsea Knotts, Justine Debelius, Curtis Tilves, Neda Dadgar, Kunhong Xiao, Ali H. Zaidi, Louis Gil Acevedo, William LaFramboise, Ni Zhao, Cynthia Sears, Noel Mueller
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Gastroenterology
Subjects:
colorectal cancer
intra-tumoral lymphocytes
CD3/CD8 quantification
prognostic biomarkers
immunoscore
Online Access:https://www.frontiersin.org/articles/10.3389/fgstr.2024.1493949/full
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