The use of cluster analysis at the development of approaches on selection and administration of treatment to HIV-infected patients
The purpose of the study is the formation production rules for selecting combinations of antiretroviral drugs for patients with HIV infection for optimal therapy.Materials and methods. The cluster analysis base is the choice of patients whose treatment can be assessed as successful. As a result of t...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2017-10-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/955 |
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| author | Nadezhda A. Gudilina El’vira S. Ivanova Andrey V. Sibiryakov Natal’ya V. Mekhonoshina Natal’ya B. Rostova Rustam A. Fayzrakhmanov |
| author_facet | Nadezhda A. Gudilina El’vira S. Ivanova Andrey V. Sibiryakov Natal’ya V. Mekhonoshina Natal’ya B. Rostova Rustam A. Fayzrakhmanov |
| author_sort | Nadezhda A. Gudilina |
| collection | DOAJ |
| description | The purpose of the study is the formation production rules for selecting combinations of antiretroviral drugs for patients with HIV infection for optimal therapy.Materials and methods. The cluster analysis base is the choice of patients whose treatment can be assessed as successful. As a result of the selection of effective treatment cases, 79 patients were left in the study out of 123 examined cards of patients treated at the Perm Regional AIDS and Infectious Diseases Center. As input parameters for the cluster analysis, the patient’s sex, the stage of the main disease at the time of antiretroviral therapy, the way of HIV infection, and presence of opportunistic diseases were selected. As an output variable, the prescribed treatment regimen was adopted. Analysis of treatment of patients (79 cases) showed that the optimal solution is using nine clusters.Results. The results of this analysis allow us to formulate production rules for the selection of antiretroviral drugs to create an expert system that allows us to optimize the rational choice, designation and use of drugs for the treatment of HIV-infected patients. |
| format | Article |
| id | doaj-art-48dcc4d4318949939d261f0ac3fdbf07 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-48dcc4d4318949939d261f0ac3fdbf072025-08-20T03:37:47ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842017-10-01163526010.20538/1682-0363-2017-3-52-60707The use of cluster analysis at the development of approaches on selection and administration of treatment to HIV-infected patientsNadezhda A. Gudilina0El’vira S. Ivanova1Andrey V. Sibiryakov2Natal’ya V. Mekhonoshina3Natal’ya B. Rostova4Rustam A. Fayzrakhmanov5Perm State Pharmaceutical AcademyaPerm Regional Center for Prevention and Control of AIDS and Infectious DiseasesPerm National Research Polytechnical UniversityPerm National Research Polytechnical UniversityPerm State Pharmaceutical AcademyaPerm National Research Polytechnical UniversityThe purpose of the study is the formation production rules for selecting combinations of antiretroviral drugs for patients with HIV infection for optimal therapy.Materials and methods. The cluster analysis base is the choice of patients whose treatment can be assessed as successful. As a result of the selection of effective treatment cases, 79 patients were left in the study out of 123 examined cards of patients treated at the Perm Regional AIDS and Infectious Diseases Center. As input parameters for the cluster analysis, the patient’s sex, the stage of the main disease at the time of antiretroviral therapy, the way of HIV infection, and presence of opportunistic diseases were selected. As an output variable, the prescribed treatment regimen was adopted. Analysis of treatment of patients (79 cases) showed that the optimal solution is using nine clusters.Results. The results of this analysis allow us to formulate production rules for the selection of antiretroviral drugs to create an expert system that allows us to optimize the rational choice, designation and use of drugs for the treatment of HIV-infected patients.https://bulletin.ssmu.ru/jour/article/view/955hiv infectionantiretroviral therapyopportunistic infectionsviral loadcd4 +-lymphocytesexpert systemcluster analysisk-means method |
| spellingShingle | Nadezhda A. Gudilina El’vira S. Ivanova Andrey V. Sibiryakov Natal’ya V. Mekhonoshina Natal’ya B. Rostova Rustam A. Fayzrakhmanov The use of cluster analysis at the development of approaches on selection and administration of treatment to HIV-infected patients Бюллетень сибирской медицины hiv infection antiretroviral therapy opportunistic infections viral load cd4 +-lymphocytes expert system cluster analysis k-means method |
| title | The use of cluster analysis at the development of approaches on selection and administration of treatment to HIV-infected patients |
| title_full | The use of cluster analysis at the development of approaches on selection and administration of treatment to HIV-infected patients |
| title_fullStr | The use of cluster analysis at the development of approaches on selection and administration of treatment to HIV-infected patients |
| title_full_unstemmed | The use of cluster analysis at the development of approaches on selection and administration of treatment to HIV-infected patients |
| title_short | The use of cluster analysis at the development of approaches on selection and administration of treatment to HIV-infected patients |
| title_sort | use of cluster analysis at the development of approaches on selection and administration of treatment to hiv infected patients |
| topic | hiv infection antiretroviral therapy opportunistic infections viral load cd4 +-lymphocytes expert system cluster analysis k-means method |
| url | https://bulletin.ssmu.ru/jour/article/view/955 |
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