Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling
Endothelial inflammation injury is a key mechanism that occurs in the pathological processes of various cardiovascular diseases. Puerarin (PUE) is an isoflavone compound with strong antioxidant properties and the main active component isolated from the rhizome of Pueraria lobata. PUE exhibits a good...
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KeAi Communications Co., Ltd.
2024-09-01
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| Series: | Journal of Holistic Integrative Pharmacy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2707368824000451 |
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| author | Xing Chang Meng Cheng Ying Li Xiuteng Zhou |
| author_facet | Xing Chang Meng Cheng Ying Li Xiuteng Zhou |
| author_sort | Xing Chang |
| collection | DOAJ |
| description | Endothelial inflammation injury is a key mechanism that occurs in the pathological processes of various cardiovascular diseases. Puerarin (PUE) is an isoflavone compound with strong antioxidant properties and the main active component isolated from the rhizome of Pueraria lobata. PUE exhibits a good anti-atherosclerotic pharmacological effect, but there are few studies on the mechanism of its protective effect on endothelial cells. This study found that PUE could regulate to some extent the mitochondrial function of human umbilical vein endothelial cells (HUVECs) and reduce or inhibit lipopolysaccharide-induced inflammatory reactions and oxidative stress injury in HUVECs. Furthermore, the protective effect of PUE on HUVECs was closely related to the SIRT-1 signaling pathway. PUE increased the level of mitophagy and the activity of mitochondrial antioxidant enzymes by increasing SIRT-1 expression, reducing excessive production of ROS, and inhibiting expression of inflammatory factors and oxidative stress injury. Therefore, PUE may improve mitochondrial respiratory function and energy metabolism and increase the activity of HUVECs in the inflammatory state. |
| format | Article |
| id | doaj-art-48d9b3a1ea764c289723a1822bc26d76 |
| institution | OA Journals |
| issn | 2707-3688 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Holistic Integrative Pharmacy |
| spelling | doaj-art-48d9b3a1ea764c289723a1822bc26d762025-08-20T02:14:00ZengKeAi Communications Co., Ltd.Journal of Holistic Integrative Pharmacy2707-36882024-09-015320521410.1016/j.jhip.2024.08.004Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signalingXing Chang0Meng Cheng1Ying Li2Xiuteng Zhou3National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences/State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Beijing, 100700, China; Guang'anmen Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing, 100053, ChinaNational Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences/State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Beijing, 100700, ChinaNational Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences/State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Beijing, 100700, ChinaNational Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences/State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Beijing, 100700, China; Corresponding author.Endothelial inflammation injury is a key mechanism that occurs in the pathological processes of various cardiovascular diseases. Puerarin (PUE) is an isoflavone compound with strong antioxidant properties and the main active component isolated from the rhizome of Pueraria lobata. PUE exhibits a good anti-atherosclerotic pharmacological effect, but there are few studies on the mechanism of its protective effect on endothelial cells. This study found that PUE could regulate to some extent the mitochondrial function of human umbilical vein endothelial cells (HUVECs) and reduce or inhibit lipopolysaccharide-induced inflammatory reactions and oxidative stress injury in HUVECs. Furthermore, the protective effect of PUE on HUVECs was closely related to the SIRT-1 signaling pathway. PUE increased the level of mitophagy and the activity of mitochondrial antioxidant enzymes by increasing SIRT-1 expression, reducing excessive production of ROS, and inhibiting expression of inflammatory factors and oxidative stress injury. Therefore, PUE may improve mitochondrial respiratory function and energy metabolism and increase the activity of HUVECs in the inflammatory state.http://www.sciencedirect.com/science/article/pii/S2707368824000451PuerarinEndothelial inflammation injuryVascularSIRT-1Mitochondrial |
| spellingShingle | Xing Chang Meng Cheng Ying Li Xiuteng Zhou Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling Journal of Holistic Integrative Pharmacy Puerarin Endothelial inflammation injury Vascular SIRT-1 Mitochondrial |
| title | Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling |
| title_full | Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling |
| title_fullStr | Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling |
| title_full_unstemmed | Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling |
| title_short | Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling |
| title_sort | puerarin alleviates lps induced endothelial cells injury via sirt1 mediated mitochondrial homeostasis signaling |
| topic | Puerarin Endothelial inflammation injury Vascular SIRT-1 Mitochondrial |
| url | http://www.sciencedirect.com/science/article/pii/S2707368824000451 |
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