Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review

BackgroundThe goal of just-in-time adaptive interventions (JITAIs) is to use mobile, digital tools to provide individuals with personalized interventions at the optimal time and in the optimal context. Accordingly, JITAIs are promising for advancing accessible, equitable, and...

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Main Authors: Lauren M Henry, Morkeh Blay-Tofey, Clara E Haeffner, Cassandra N Raymond, Elizabeth Tandilashvili, Nancy Terry, Miryam Kiderman, Olivia Metcalf, Melissa A Brotman, Silvia Lopez-Guzman
Format: Article
Language:English
Published: JMIR Publications 2025-02-01
Series:JMIR Research Protocols
Online Access:https://www.researchprotocols.org/2025/1/e58917
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author Lauren M Henry
Morkeh Blay-Tofey
Clara E Haeffner
Cassandra N Raymond
Elizabeth Tandilashvili
Nancy Terry
Miryam Kiderman
Olivia Metcalf
Melissa A Brotman
Silvia Lopez-Guzman
author_facet Lauren M Henry
Morkeh Blay-Tofey
Clara E Haeffner
Cassandra N Raymond
Elizabeth Tandilashvili
Nancy Terry
Miryam Kiderman
Olivia Metcalf
Melissa A Brotman
Silvia Lopez-Guzman
author_sort Lauren M Henry
collection DOAJ
description BackgroundThe goal of just-in-time adaptive interventions (JITAIs) is to use mobile, digital tools to provide individuals with personalized interventions at the optimal time and in the optimal context. Accordingly, JITAIs are promising for advancing accessible, equitable, and evidence-based treatment for behavioral health. To guide future inquiry in this space, a review of the literature is needed to describe the state of research on JITAIs for behavioral health. ObjectiveThis study aims to systematically review the literature to describe the landscape of existing JITAIs for behavioral health at any stage of intervention development. In addition, conditional upon a sufficiently homogeneous literature, we will conduct meta-analyses to investigate the effectiveness of JITAIs for promoting distal outcomes (here, aspects of behavioral health) and proximal outcomes (eg, emotion regulation). MethodsThis systematic review is being conducted in accordance with the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols). We developed our search strategy and executed the literature search in collaboration with biomedical librarians; 5 databases (PubMed, Embase, Cochrane Library, Web of Science: Core Collection, and APA PsycINFO) were searched, and results were managed using EndNote 20 (Clarivate). We are screening (title, abstract, and full text) all records in duplicate in Covidence according to eligibility criteria. Data items will be extracted, and risk of bias will be assessed in duplicate from the included articles in Covidence. We will summarize JITAI characteristics in tables and text. We will conduct meta-analyses for the distal and proximal outcomes conditional upon sufficient homogeneity in subgroups. Moderation (conditional upon sufficient heterogeneity of outcomes) and mediation (ie, whether changes in proximal outcomes mediate the relation between JITAIs and distal outcomes) will be conducted as appropriate. We will investigate publication bias and use the Grading of Recommendations Assessment, Development and Evaluation to characterize the quality of evidence of our estimates. ResultsThe search strategy was developed between July 2023 and November 2023. The literature search was executed between November 2023 and December 2023. Title and abstract screening began in December 2023, and full-text screening began in May 2024. Data extraction and analyses have not begun. ConclusionsHere, we propose a systematic review to assess the state of the literature on JITAIs for behavioral health. The insights derived from this study will describe the literature on JITAIs in promoting behavioral health, reinforce JITAI definitions, clarify JITAI elements, and inform the next steps in JITAI research. International Registered Report Identifier (IRRID)PRR1-10.2196/58917
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institution Kabale University
issn 1929-0748
language English
publishDate 2025-02-01
publisher JMIR Publications
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series JMIR Research Protocols
spelling doaj-art-48d7b1230cda49bf80d26bffc8ea65022025-02-11T15:46:08ZengJMIR PublicationsJMIR Research Protocols1929-07482025-02-0114e5891710.2196/58917Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic ReviewLauren M Henryhttps://orcid.org/0000-0003-0286-9319Morkeh Blay-Tofeyhttps://orcid.org/0009-0000-2320-838XClara E Haeffnerhttps://orcid.org/0000-0002-7676-8951Cassandra N Raymondhttps://orcid.org/0009-0003-1027-7126Elizabeth Tandilashvilihttps://orcid.org/0009-0005-6971-0080Nancy Terryhttps://orcid.org/0000-0002-3884-8379Miryam Kidermanhttps://orcid.org/0000-0002-2701-8484Olivia Metcalfhttps://orcid.org/0000-0001-9570-8463Melissa A Brotmanhttps://orcid.org/0000-0002-9859-4702Silvia Lopez-Guzmanhttps://orcid.org/0000-0003-0271-3576 BackgroundThe goal of just-in-time adaptive interventions (JITAIs) is to use mobile, digital tools to provide individuals with personalized interventions at the optimal time and in the optimal context. Accordingly, JITAIs are promising for advancing accessible, equitable, and evidence-based treatment for behavioral health. To guide future inquiry in this space, a review of the literature is needed to describe the state of research on JITAIs for behavioral health. ObjectiveThis study aims to systematically review the literature to describe the landscape of existing JITAIs for behavioral health at any stage of intervention development. In addition, conditional upon a sufficiently homogeneous literature, we will conduct meta-analyses to investigate the effectiveness of JITAIs for promoting distal outcomes (here, aspects of behavioral health) and proximal outcomes (eg, emotion regulation). MethodsThis systematic review is being conducted in accordance with the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols). We developed our search strategy and executed the literature search in collaboration with biomedical librarians; 5 databases (PubMed, Embase, Cochrane Library, Web of Science: Core Collection, and APA PsycINFO) were searched, and results were managed using EndNote 20 (Clarivate). We are screening (title, abstract, and full text) all records in duplicate in Covidence according to eligibility criteria. Data items will be extracted, and risk of bias will be assessed in duplicate from the included articles in Covidence. We will summarize JITAI characteristics in tables and text. We will conduct meta-analyses for the distal and proximal outcomes conditional upon sufficient homogeneity in subgroups. Moderation (conditional upon sufficient heterogeneity of outcomes) and mediation (ie, whether changes in proximal outcomes mediate the relation between JITAIs and distal outcomes) will be conducted as appropriate. We will investigate publication bias and use the Grading of Recommendations Assessment, Development and Evaluation to characterize the quality of evidence of our estimates. ResultsThe search strategy was developed between July 2023 and November 2023. The literature search was executed between November 2023 and December 2023. Title and abstract screening began in December 2023, and full-text screening began in May 2024. Data extraction and analyses have not begun. ConclusionsHere, we propose a systematic review to assess the state of the literature on JITAIs for behavioral health. The insights derived from this study will describe the literature on JITAIs in promoting behavioral health, reinforce JITAI definitions, clarify JITAI elements, and inform the next steps in JITAI research. International Registered Report Identifier (IRRID)PRR1-10.2196/58917https://www.researchprotocols.org/2025/1/e58917
spellingShingle Lauren M Henry
Morkeh Blay-Tofey
Clara E Haeffner
Cassandra N Raymond
Elizabeth Tandilashvili
Nancy Terry
Miryam Kiderman
Olivia Metcalf
Melissa A Brotman
Silvia Lopez-Guzman
Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review
JMIR Research Protocols
title Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review
title_full Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review
title_fullStr Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review
title_full_unstemmed Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review
title_short Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review
title_sort just in time adaptive interventions to promote behavioral health protocol for a systematic review
url https://www.researchprotocols.org/2025/1/e58917
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