Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular Vesicles
Extracellular vesicles (EVs) are small, membrane-bound particles secreted by cells into the extracellular environment, playing an increasingly recognized role in inter-organ communication and the regulation of various physiological processes. Regarding the redox homeostasis context, EVs play a pivot...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/12/1493 |
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| author | Javier Huete-Acevedo Cristina Mas-Bargues Marta Arnal-Forné Sandra Atencia-Rabadán Jorge Sanz-Ros Consuelo Borrás |
| author_facet | Javier Huete-Acevedo Cristina Mas-Bargues Marta Arnal-Forné Sandra Atencia-Rabadán Jorge Sanz-Ros Consuelo Borrás |
| author_sort | Javier Huete-Acevedo |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are small, membrane-bound particles secreted by cells into the extracellular environment, playing an increasingly recognized role in inter-organ communication and the regulation of various physiological processes. Regarding the redox homeostasis context, EVs play a pivotal role in propagating and mitigating oxidative stress signals across different organs. Cells under oxidative stress release EVs containing signaling molecules that can influence the redox status of distant cells and tissues. EVs are starting to be recognized as contributors to brain-liver communication. Therefore, in this review, we show how redox imbalance can affect the release of EVs in the brain and liver. We propose EVs as mediators of redox homeostasis in the brain-liver axis. |
| format | Article |
| id | doaj-art-48d6f7bcabcc4968800eb7b03174f01a |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-48d6f7bcabcc4968800eb7b03174f01a2025-08-20T02:53:34ZengMDPI AGAntioxidants2076-39212024-12-011312149310.3390/antiox13121493Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular VesiclesJavier Huete-Acevedo0Cristina Mas-Bargues1Marta Arnal-Forné2Sandra Atencia-Rabadán3Jorge Sanz-Ros4Consuelo Borrás5MiniAging Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibáñez, 15, 46010 Valencia, SpainMiniAging Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibáñez, 15, 46010 Valencia, SpainMiniAging Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibáñez, 15, 46010 Valencia, SpainMiniAging Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibáñez, 15, 46010 Valencia, SpainDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USAMiniAging Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibáñez, 15, 46010 Valencia, SpainExtracellular vesicles (EVs) are small, membrane-bound particles secreted by cells into the extracellular environment, playing an increasingly recognized role in inter-organ communication and the regulation of various physiological processes. Regarding the redox homeostasis context, EVs play a pivotal role in propagating and mitigating oxidative stress signals across different organs. Cells under oxidative stress release EVs containing signaling molecules that can influence the redox status of distant cells and tissues. EVs are starting to be recognized as contributors to brain-liver communication. Therefore, in this review, we show how redox imbalance can affect the release of EVs in the brain and liver. We propose EVs as mediators of redox homeostasis in the brain-liver axis.https://www.mdpi.com/2076-3921/13/12/1493extracellular vesiclesredox homeostasisbrain-liver axis |
| spellingShingle | Javier Huete-Acevedo Cristina Mas-Bargues Marta Arnal-Forné Sandra Atencia-Rabadán Jorge Sanz-Ros Consuelo Borrás Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular Vesicles Antioxidants extracellular vesicles redox homeostasis brain-liver axis |
| title | Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular Vesicles |
| title_full | Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular Vesicles |
| title_fullStr | Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular Vesicles |
| title_full_unstemmed | Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular Vesicles |
| title_short | Role of Redox Homeostasis in the Communication Between Brain and Liver Through Extracellular Vesicles |
| title_sort | role of redox homeostasis in the communication between brain and liver through extracellular vesicles |
| topic | extracellular vesicles redox homeostasis brain-liver axis |
| url | https://www.mdpi.com/2076-3921/13/12/1493 |
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