Clinical Manifestations of Symptomatic Intracranial Hemorrhage in Term Neonates: 18 Years of Experience in a Medical Center
Intracranial hemorrhage (ICH) is an uncommon but important cause of morbidity and mortality in term neonates. We conducted a retrospective analysis of the clinical characteristics and developmental outcomes of symptomatic ICH in term neonates. Methods: A retrospective chart review was conducted of a...
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Elsevier
2010-08-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S187595721060040X |
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| author | Mei-Chen Ou-Yang Chung-Bin Huang Hsin-Chun Huang Mei-Yung Chung Chih-Cheng Chen Feng-Shun Chen Pei-Hsin Chao I-Lun Chen Mei-Hui Ou-Yang Chieh-An Liu |
| author_facet | Mei-Chen Ou-Yang Chung-Bin Huang Hsin-Chun Huang Mei-Yung Chung Chih-Cheng Chen Feng-Shun Chen Pei-Hsin Chao I-Lun Chen Mei-Hui Ou-Yang Chieh-An Liu |
| author_sort | Mei-Chen Ou-Yang |
| collection | DOAJ |
| description | Intracranial hemorrhage (ICH) is an uncommon but important cause of morbidity and mortality in term neonates. We conducted a retrospective analysis of the clinical characteristics and developmental outcomes of symptomatic ICH in term neonates.
Methods: A retrospective chart review was conducted of all term neonates (less than 1 month old) diagnosed with ICH and admitted to the neonatal intensive care unit of Kaohsiung Chang Gung Hospital from December 1991 to December 2008. Demographic characteristics, mode of delivery, laboratory data, clinical presentation, and developmental status were recorded.
Results: Data for 24 term neonates (17 boys and 7 girls) with a diagnosis of ICH were collected for analysis. The clinical manifestations of ICH included anemia (13/24, 54%), seizure (11/24, 46%), cyanosis (7/24, 29%), tachypnea (5/24, 21%), fever (1/24, 4%), hypothermia (1/24, 4%), and poor feeding (1/24, 4%). Age at symptom onset ranged from 2 hours to 11 days following birth. The most common type of ICH was subdural hemorrhage. All ICHs resolved, except in one infant, who died from hypoxicischemic encephalopathy at 25 days. Ten children with symptomatic ICH were reported to have normal development, while the remainder (13/23, 57%) showed developmental delays or disabilities.
Conclusion: Unexplained anemia, seizure, and cyanosis were the major presenting signs in infants with symptomatic ICH. A diagnosis of ICH should be considered in term neonates who present with one or more of these signs. Although the mortality in term infants with symptomatic ICH was low, more than half |
| format | Article |
| id | doaj-art-48d43ef3bf3e4c9cb97a001b740bf919 |
| institution | Kabale University |
| issn | 1875-9572 |
| language | English |
| publishDate | 2010-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-48d43ef3bf3e4c9cb97a001b740bf9192025-08-20T03:52:25ZengElsevierPediatrics and Neonatology1875-95722010-08-0151420821310.1016/S1875-9572(10)60040-XClinical Manifestations of Symptomatic Intracranial Hemorrhage in Term Neonates: 18 Years of Experience in a Medical CenterMei-Chen Ou-Yang0Chung-Bin Huang1Hsin-Chun Huang2Mei-Yung Chung3Chih-Cheng Chen4Feng-Shun Chen5Pei-Hsin Chao6I-Lun Chen7Mei-Hui Ou-Yang8Chieh-An Liu9Division of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chiayi, TaiwanDepartment of Pediatrics, Kuang Tien General Hospital, Taichung, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, TaiwanSan An Hospital, Kaohsiung, TaiwanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital, Kaohsiung, TaiwanIntracranial hemorrhage (ICH) is an uncommon but important cause of morbidity and mortality in term neonates. We conducted a retrospective analysis of the clinical characteristics and developmental outcomes of symptomatic ICH in term neonates. Methods: A retrospective chart review was conducted of all term neonates (less than 1 month old) diagnosed with ICH and admitted to the neonatal intensive care unit of Kaohsiung Chang Gung Hospital from December 1991 to December 2008. Demographic characteristics, mode of delivery, laboratory data, clinical presentation, and developmental status were recorded. Results: Data for 24 term neonates (17 boys and 7 girls) with a diagnosis of ICH were collected for analysis. The clinical manifestations of ICH included anemia (13/24, 54%), seizure (11/24, 46%), cyanosis (7/24, 29%), tachypnea (5/24, 21%), fever (1/24, 4%), hypothermia (1/24, 4%), and poor feeding (1/24, 4%). Age at symptom onset ranged from 2 hours to 11 days following birth. The most common type of ICH was subdural hemorrhage. All ICHs resolved, except in one infant, who died from hypoxicischemic encephalopathy at 25 days. Ten children with symptomatic ICH were reported to have normal development, while the remainder (13/23, 57%) showed developmental delays or disabilities. Conclusion: Unexplained anemia, seizure, and cyanosis were the major presenting signs in infants with symptomatic ICH. A diagnosis of ICH should be considered in term neonates who present with one or more of these signs. Although the mortality in term infants with symptomatic ICH was low, more than halfhttp://www.sciencedirect.com/science/article/pii/S187595721060040Xintracranial hemorrhageoutcomesterm neonates |
| spellingShingle | Mei-Chen Ou-Yang Chung-Bin Huang Hsin-Chun Huang Mei-Yung Chung Chih-Cheng Chen Feng-Shun Chen Pei-Hsin Chao I-Lun Chen Mei-Hui Ou-Yang Chieh-An Liu Clinical Manifestations of Symptomatic Intracranial Hemorrhage in Term Neonates: 18 Years of Experience in a Medical Center Pediatrics and Neonatology intracranial hemorrhage outcomes term neonates |
| title | Clinical Manifestations of Symptomatic Intracranial Hemorrhage in Term Neonates: 18 Years of Experience in a Medical Center |
| title_full | Clinical Manifestations of Symptomatic Intracranial Hemorrhage in Term Neonates: 18 Years of Experience in a Medical Center |
| title_fullStr | Clinical Manifestations of Symptomatic Intracranial Hemorrhage in Term Neonates: 18 Years of Experience in a Medical Center |
| title_full_unstemmed | Clinical Manifestations of Symptomatic Intracranial Hemorrhage in Term Neonates: 18 Years of Experience in a Medical Center |
| title_short | Clinical Manifestations of Symptomatic Intracranial Hemorrhage in Term Neonates: 18 Years of Experience in a Medical Center |
| title_sort | clinical manifestations of symptomatic intracranial hemorrhage in term neonates 18 years of experience in a medical center |
| topic | intracranial hemorrhage outcomes term neonates |
| url | http://www.sciencedirect.com/science/article/pii/S187595721060040X |
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