Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without Effect on Weight
Aims. Major aims were to determine whether exposure to the commonly used food additive carrageenan could induce fasting hyperglycemia and could increase the effects of a high fat diet on glucose intolerance and dyslipidemia. Methods. C57BL/6J mice were exposed to either carrageenan, high fat diet, o...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/513429 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565774514913280 |
|---|---|
| author | Sumit Bhattacharyya Leo Feferman Terry Unterman Joanne K. Tobacman |
| author_facet | Sumit Bhattacharyya Leo Feferman Terry Unterman Joanne K. Tobacman |
| author_sort | Sumit Bhattacharyya |
| collection | DOAJ |
| description | Aims. Major aims were to determine whether exposure to the commonly used food additive carrageenan could induce fasting hyperglycemia and could increase the effects of a high fat diet on glucose intolerance and dyslipidemia. Methods. C57BL/6J mice were exposed to either carrageenan, high fat diet, or the combination of high fat diet and carrageenan, or untreated, for one year. Effects on fasting blood glucose, glucose tolerance, lipid parameters, weight, glycogen stores, and inflammation were compared. Results. Exposure to carrageenan led to glucose intolerance by six days and produced elevated fasting blood glucose by 23 weeks. Effects of carrageenan on glucose tolerance were more severe than from high fat alone. Carrageenan in combination with high fat produced earlier onset of fasting hyperglycemia and higher glucose levels in glucose tolerance tests and exacerbated dyslipidemia. In contrast to high fat, carrageenan did not lead to weight gain. In hyperinsulinemic, euglycemic clamp studies, the carrageenan-exposed mice had higher early glucose levels and lower glucose infusion rate and longer interval to achieve the steady-state. Conclusions. Carrageenan in the Western diet may contribute to the development of diabetes and the effects of high fat consumption. Carrageenan may be useful as a nonobese model of diabetes in the mouse. |
| format | Article |
| id | doaj-art-48d217052f394159a1708853dbf981ea |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-48d217052f394159a1708853dbf981ea2025-02-03T01:06:41ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/513429513429Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without Effect on WeightSumit Bhattacharyya0Leo Feferman1Terry Unterman2Joanne K. Tobacman3Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612-4325, USADepartment of Medicine, University of Illinois at Chicago, Chicago, IL 60612-4325, USADepartment of Medicine, University of Illinois at Chicago, Chicago, IL 60612-4325, USADepartment of Medicine, University of Illinois at Chicago, Chicago, IL 60612-4325, USAAims. Major aims were to determine whether exposure to the commonly used food additive carrageenan could induce fasting hyperglycemia and could increase the effects of a high fat diet on glucose intolerance and dyslipidemia. Methods. C57BL/6J mice were exposed to either carrageenan, high fat diet, or the combination of high fat diet and carrageenan, or untreated, for one year. Effects on fasting blood glucose, glucose tolerance, lipid parameters, weight, glycogen stores, and inflammation were compared. Results. Exposure to carrageenan led to glucose intolerance by six days and produced elevated fasting blood glucose by 23 weeks. Effects of carrageenan on glucose tolerance were more severe than from high fat alone. Carrageenan in combination with high fat produced earlier onset of fasting hyperglycemia and higher glucose levels in glucose tolerance tests and exacerbated dyslipidemia. In contrast to high fat, carrageenan did not lead to weight gain. In hyperinsulinemic, euglycemic clamp studies, the carrageenan-exposed mice had higher early glucose levels and lower glucose infusion rate and longer interval to achieve the steady-state. Conclusions. Carrageenan in the Western diet may contribute to the development of diabetes and the effects of high fat consumption. Carrageenan may be useful as a nonobese model of diabetes in the mouse.http://dx.doi.org/10.1155/2015/513429 |
| spellingShingle | Sumit Bhattacharyya Leo Feferman Terry Unterman Joanne K. Tobacman Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without Effect on Weight Journal of Diabetes Research |
| title | Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without Effect on Weight |
| title_full | Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without Effect on Weight |
| title_fullStr | Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without Effect on Weight |
| title_full_unstemmed | Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without Effect on Weight |
| title_short | Exposure to Common Food Additive Carrageenan Alone Leads to Fasting Hyperglycemia and in Combination with High Fat Diet Exacerbates Glucose Intolerance and Hyperlipidemia without Effect on Weight |
| title_sort | exposure to common food additive carrageenan alone leads to fasting hyperglycemia and in combination with high fat diet exacerbates glucose intolerance and hyperlipidemia without effect on weight |
| url | http://dx.doi.org/10.1155/2015/513429 |
| work_keys_str_mv | AT sumitbhattacharyya exposuretocommonfoodadditivecarrageenanaloneleadstofastinghyperglycemiaandincombinationwithhighfatdietexacerbatesglucoseintoleranceandhyperlipidemiawithouteffectonweight AT leofeferman exposuretocommonfoodadditivecarrageenanaloneleadstofastinghyperglycemiaandincombinationwithhighfatdietexacerbatesglucoseintoleranceandhyperlipidemiawithouteffectonweight AT terryunterman exposuretocommonfoodadditivecarrageenanaloneleadstofastinghyperglycemiaandincombinationwithhighfatdietexacerbatesglucoseintoleranceandhyperlipidemiawithouteffectonweight AT joannektobacman exposuretocommonfoodadditivecarrageenanaloneleadstofastinghyperglycemiaandincombinationwithhighfatdietexacerbatesglucoseintoleranceandhyperlipidemiawithouteffectonweight |