Structural insights into thyroid hormone transporter MCT8

Abstract Thyroid hormones (THs), including T4 (3,5,3′,5′-tetraiodo-L-thyronine) and T3 (3,5,3′-triiodo-L-thyronine), play critical roles in regulating tissue development and basal metabolism. Monocarboxylate transporter 8 (MCT8) is a key player in TH transport, known for its high specificity and aff...

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Bibliographic Details
Main Authors: Jiaxin Tan, Yuan Xiao, Fang Kong, Jiawei Qian, Angqi Zhu, Chuangye Yan
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58131-8
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