Structural insights into thyroid hormone transporter MCT8
Abstract Thyroid hormones (THs), including T4 (3,5,3′,5′-tetraiodo-L-thyronine) and T3 (3,5,3′-triiodo-L-thyronine), play critical roles in regulating tissue development and basal metabolism. Monocarboxylate transporter 8 (MCT8) is a key player in TH transport, known for its high specificity and aff...
Saved in:
| Main Authors: | Jiaxin Tan, Yuan Xiao, Fang Kong, Jiawei Qian, Angqi Zhu, Chuangye Yan |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-58131-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Toward a treatment for thyroid hormone transporter MCT8 deficiency – achievements and challenges
by: Boyka Markova, et al.
Published: (2024-11-01) -
Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration
by: Stefan Groeneweg, et al.
Published: (2025-03-01) -
Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice
by: Steffen Mayerl, et al.
Published: (2025-02-01) -
Pathogenic MCT8V235L creates a steric clash that is alleviated by a compensating mutation of MCT8F285A
by: Niklas Sonntag, et al.
Published: (2025-06-01) -
Effects of intermittent training on anaerobic performance and MCT transporters in athletes.
by: Grégoire Millet, et al.
Published: (2014-01-01)