Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders

Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence...

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Main Authors: Hao Qian, Na Luo, Yuling Chi
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Journal of Aging Research
Online Access:http://dx.doi.org/10.1155/2012/121390
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author Hao Qian
Na Luo
Yuling Chi
author_facet Hao Qian
Na Luo
Yuling Chi
author_sort Hao Qian
collection DOAJ
description Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. In this review we summarize currently available information on aging-shifted prostaglandin profiles in endothelium and how these shifts are associated with cardiovascular disorders, providing one molecular mechanism of age-associated endothelium dysfunction and cardiovascular diseases.
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institution Kabale University
issn 2090-2204
2090-2212
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publishDate 2012-01-01
publisher Wiley
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series Journal of Aging Research
spelling doaj-art-48c8036d34004dfca631b64e677751f82025-02-03T06:08:32ZengWileyJournal of Aging Research2090-22042090-22122012-01-01201210.1155/2012/121390121390Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular DisordersHao Qian0Na Luo1Yuling Chi2Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USAAge-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. In this review we summarize currently available information on aging-shifted prostaglandin profiles in endothelium and how these shifts are associated with cardiovascular disorders, providing one molecular mechanism of age-associated endothelium dysfunction and cardiovascular diseases.http://dx.doi.org/10.1155/2012/121390
spellingShingle Hao Qian
Na Luo
Yuling Chi
Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders
Journal of Aging Research
title Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders
title_full Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders
title_fullStr Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders
title_full_unstemmed Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders
title_short Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders
title_sort aging shifted prostaglandin profile in endothelium as a factor in cardiovascular disorders
url http://dx.doi.org/10.1155/2012/121390
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AT naluo agingshiftedprostaglandinprofileinendotheliumasafactorincardiovasculardisorders
AT yulingchi agingshiftedprostaglandinprofileinendotheliumasafactorincardiovasculardisorders