Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders
Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2012/121390 |
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| _version_ | 1832549789264248832 |
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| author | Hao Qian Na Luo Yuling Chi |
| author_facet | Hao Qian Na Luo Yuling Chi |
| author_sort | Hao Qian |
| collection | DOAJ |
| description | Age-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. In this review we summarize currently available information on aging-shifted prostaglandin profiles in endothelium and how these shifts are associated with cardiovascular disorders, providing one molecular mechanism of age-associated endothelium dysfunction and cardiovascular diseases. |
| format | Article |
| id | doaj-art-48c8036d34004dfca631b64e677751f8 |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-48c8036d34004dfca631b64e677751f82025-02-03T06:08:32ZengWileyJournal of Aging Research2090-22042090-22122012-01-01201210.1155/2012/121390121390Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular DisordersHao Qian0Na Luo1Yuling Chi2Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USADepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USAAge-associated endothelium dysfunction is a major risk factor for the development of cardiovascular diseases. Endothelium-synthesized prostaglandins and thromboxane are local hormones, which mediate vasodilation and vasoconstriction and critically maintain vascular homeostasis. Accumulating evidence indicates that the age-related changes in endothelial eicosanoids contribute to decline in endothelium function and are associated with pathological dysfunction. In this review we summarize currently available information on aging-shifted prostaglandin profiles in endothelium and how these shifts are associated with cardiovascular disorders, providing one molecular mechanism of age-associated endothelium dysfunction and cardiovascular diseases.http://dx.doi.org/10.1155/2012/121390 |
| spellingShingle | Hao Qian Na Luo Yuling Chi Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders Journal of Aging Research |
| title | Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders |
| title_full | Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders |
| title_fullStr | Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders |
| title_full_unstemmed | Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders |
| title_short | Aging-Shifted Prostaglandin Profile in Endothelium as a Factor in Cardiovascular Disorders |
| title_sort | aging shifted prostaglandin profile in endothelium as a factor in cardiovascular disorders |
| url | http://dx.doi.org/10.1155/2012/121390 |
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