The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans
Aging is associated with increased central aortic systolic pressure (CSP) and pulse pressure which are predictive of cardiovascular events. Mechanisms implicated for higher central pressures include a higher forward incident pressure wave (P1), higher augmented pressure (AP), and shorter reflected w...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/585703 |
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| author | Haroon Kamran Jason M. Lazar Rinkesh Patel IIir Maraj Heather Berman Louis Salciccioli |
| author_facet | Haroon Kamran Jason M. Lazar Rinkesh Patel IIir Maraj Heather Berman Louis Salciccioli |
| author_sort | Haroon Kamran |
| collection | DOAJ |
| description | Aging is associated with increased central aortic systolic pressure (CSP) and pulse pressure which are predictive of cardiovascular events. Mechanisms implicated for higher central pressures include a higher forward incident pressure wave (P1), higher augmented pressure (AP), and shorter reflected wave round trip travel time (Tr). African-Americans (AA) have more frequent and deleterious blood pressure elevation. Using applanation tonometry, we studied the association of age and CSP with P1 and AP in 900 AA subjects. Data showed that in subjects ≤50 years old, CSP was mediated by AP but not P1 or Tr, whereas in those >50, CSP was mediated by both AP and P1 and to a lesser extent by Tr. Predictive models were significant (𝑅2=0.97) for both age groups. In conclusion, wave reflection is the primary determinant of CSP in younger AA, while in older subjects, CSP is mediated by both the magnitude and timing of wave reflection as well as aortic impedance. |
| format | Article |
| id | doaj-art-48c69817336f4dc3b99afa4f9cb1760f |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-48c69817336f4dc3b99afa4f9cb1760f2025-08-20T03:36:47ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/585703585703The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-AmericansHaroon Kamran0Jason M. Lazar1Rinkesh Patel2IIir Maraj3Heather Berman4Louis Salciccioli5Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY 11203-2098, USADivision of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY 11203-2098, USADivision of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY 11203-2098, USADivision of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY 11203-2098, USADivision of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY 11203-2098, USADivision of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY 11203-2098, USAAging is associated with increased central aortic systolic pressure (CSP) and pulse pressure which are predictive of cardiovascular events. Mechanisms implicated for higher central pressures include a higher forward incident pressure wave (P1), higher augmented pressure (AP), and shorter reflected wave round trip travel time (Tr). African-Americans (AA) have more frequent and deleterious blood pressure elevation. Using applanation tonometry, we studied the association of age and CSP with P1 and AP in 900 AA subjects. Data showed that in subjects ≤50 years old, CSP was mediated by AP but not P1 or Tr, whereas in those >50, CSP was mediated by both AP and P1 and to a lesser extent by Tr. Predictive models were significant (𝑅2=0.97) for both age groups. In conclusion, wave reflection is the primary determinant of CSP in younger AA, while in older subjects, CSP is mediated by both the magnitude and timing of wave reflection as well as aortic impedance.http://dx.doi.org/10.4061/2011/585703 |
| spellingShingle | Haroon Kamran Jason M. Lazar Rinkesh Patel IIir Maraj Heather Berman Louis Salciccioli The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans International Journal of Hypertension |
| title | The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans |
| title_full | The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans |
| title_fullStr | The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans |
| title_full_unstemmed | The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans |
| title_short | The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans |
| title_sort | age dependent contribution of aortic incident and reflected pressure waves to central blood pressure in african americans |
| url | http://dx.doi.org/10.4061/2011/585703 |
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