Structural Activity Relationship Analysis of New Diphenyl PFI-3 Analogues Targeting for the Treatment of Glioblastoma

Structural Activity Relationship Analysis of New Diphenyl PFI-3 Analogues Targeting for the Treatment of Glioblastoma

<b data-eusoft-scrollable-element="1">Background/Objectives</b>: Human glioblastoma (GBM) is the most aggressive brain cancer in adults and a highly treatment-refractory malignancy. The overall prognosis for the GBM is extremely poor, with a median survival of 12–14 months afte...

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Bibliographic Details
Main Authors: Dong-Jin Hwang, Chuanhe Yang, Yinan Wang, Hannah Kelso, Satyanarayana Pochampally, Lawrence M. Pfeffer, Duane D. Miller
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceuticals
Subjects:
bromodomain
glioblastoma (GBM)
therapeutic enhancing drug (TED)
anti-GBM activity
structure–activity relationship (SAR)
PFI-3 analog
Online Access:https://www.mdpi.com/1424-8247/18/5/608
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