HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype
The present study investigated the frequencies of rs1800450 (MBL ⁎B, G>A), rs1800451 (MBL ⁎C, G>A), and rs5030737 (MBL ⁎D, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; n=65), h...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3718451 |
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| author | Tuane Carolina Ferreira Moura Ednelza da Silva Graça Amoras Mauro Sérgio Araújo Maria Alice Freitas Queiroz Simone Regina Souza da Silva Conde Sâmia Demachki Rosimar Neris Martins-Feitosa Luiz Fernando Almeida Machado Izaura Maria Vieira Cayres-Vallinoto Ricardo Ishak Antonio Carlos Rosário Vallinoto |
| author_facet | Tuane Carolina Ferreira Moura Ednelza da Silva Graça Amoras Mauro Sérgio Araújo Maria Alice Freitas Queiroz Simone Regina Souza da Silva Conde Sâmia Demachki Rosimar Neris Martins-Feitosa Luiz Fernando Almeida Machado Izaura Maria Vieira Cayres-Vallinoto Ricardo Ishak Antonio Carlos Rosário Vallinoto |
| author_sort | Tuane Carolina Ferreira Moura |
| collection | DOAJ |
| description | The present study investigated the frequencies of rs1800450 (MBL ⁎B, G>A), rs1800451 (MBL ⁎C, G>A), and rs5030737 (MBL ⁎D, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; n=65), hepatitis C virus (HCV; n=92), and a noninfected control group (n=300) were investigated. The presence of polymorphisms was detected using a real-time polymerase chain reaction to correlate with liver disease pathogenesis and fibrosis staging according to the Metavir classification. The genotypic and allelic frequencies showed no significant differences between the groups, but patients with active HBV and the wild AA genotype presented a positive correlation between increased transaminase and HBV DNA levels and the presence of mild to moderate fibrosis. Patients with HCV and the wild AA genotype presented mild inflammation and higher HCV RNA levels, although the same association was not observed for the fibrosis scores. The results suggest that the mutations in exon 1 of the MBL2 gene do not contribute directly to the clinical and laboratory features of HCV and HBV infections, but further studies should be performed to confirm whether the wild AA genotype has indirect effect on disease progression. |
| format | Article |
| id | doaj-art-48c3eb03d3c94ecaa7aa3e7f0efe0b85 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-48c3eb03d3c94ecaa7aa3e7f0efe0b852025-08-20T02:05:55ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/37184513718451HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA GenotypeTuane Carolina Ferreira Moura0Ednelza da Silva Graça Amoras1Mauro Sérgio Araújo2Maria Alice Freitas Queiroz3Simone Regina Souza da Silva Conde4Sâmia Demachki5Rosimar Neris Martins-Feitosa6Luiz Fernando Almeida Machado7Izaura Maria Vieira Cayres-Vallinoto8Ricardo Ishak9Antonio Carlos Rosário Vallinoto10Laboratory of Virology, Institute of Biological Sciences, Universidade Federal do Pará (UFPA), Guamá, 66075-110 Belém, PA, BrazilLaboratory of Virology, Institute of Biological Sciences, Universidade Federal do Pará (UFPA), Guamá, 66075-110 Belém, PA, BrazilLaboratory of Virology, Institute of Biological Sciences, Universidade Federal do Pará (UFPA), Guamá, 66075-110 Belém, PA, BrazilLaboratory of Virology, Institute of Biological Sciences, Universidade Federal do Pará (UFPA), Guamá, 66075-110 Belém, PA, BrazilSchool of Medicine, Institute of Health Sciences, Universidade Federal do Pará (UFPA), Umarizal, 66055-380 Belém, PA, BrazilSchool of Medicine, Institute of Health Sciences, Universidade Federal do Pará (UFPA), Umarizal, 66055-380 Belém, PA, BrazilLaboratory of Virology, Institute of Biological Sciences, Universidade Federal do Pará (UFPA), Guamá, 66075-110 Belém, PA, BrazilLaboratory of Virology, Institute of Biological Sciences, Universidade Federal do Pará (UFPA), Guamá, 66075-110 Belém, PA, BrazilLaboratory of Virology, Institute of Biological Sciences, Universidade Federal do Pará (UFPA), Guamá, 66075-110 Belém, PA, BrazilLaboratory of Virology, Institute of Biological Sciences, Universidade Federal do Pará (UFPA), Guamá, 66075-110 Belém, PA, BrazilLaboratory of Virology, Institute of Biological Sciences, Universidade Federal do Pará (UFPA), Guamá, 66075-110 Belém, PA, BrazilThe present study investigated the frequencies of rs1800450 (MBL ⁎B, G>A), rs1800451 (MBL ⁎C, G>A), and rs5030737 (MBL ⁎D, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; n=65), hepatitis C virus (HCV; n=92), and a noninfected control group (n=300) were investigated. The presence of polymorphisms was detected using a real-time polymerase chain reaction to correlate with liver disease pathogenesis and fibrosis staging according to the Metavir classification. The genotypic and allelic frequencies showed no significant differences between the groups, but patients with active HBV and the wild AA genotype presented a positive correlation between increased transaminase and HBV DNA levels and the presence of mild to moderate fibrosis. Patients with HCV and the wild AA genotype presented mild inflammation and higher HCV RNA levels, although the same association was not observed for the fibrosis scores. The results suggest that the mutations in exon 1 of the MBL2 gene do not contribute directly to the clinical and laboratory features of HCV and HBV infections, but further studies should be performed to confirm whether the wild AA genotype has indirect effect on disease progression.http://dx.doi.org/10.1155/2017/3718451 |
| spellingShingle | Tuane Carolina Ferreira Moura Ednelza da Silva Graça Amoras Mauro Sérgio Araújo Maria Alice Freitas Queiroz Simone Regina Souza da Silva Conde Sâmia Demachki Rosimar Neris Martins-Feitosa Luiz Fernando Almeida Machado Izaura Maria Vieira Cayres-Vallinoto Ricardo Ishak Antonio Carlos Rosário Vallinoto HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype Mediators of Inflammation |
| title | HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype |
| title_full | HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype |
| title_fullStr | HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype |
| title_full_unstemmed | HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype |
| title_short | HBV Viral Load and Liver Enzyme Levels May Be Associated with the Wild MBL2 AA Genotype |
| title_sort | hbv viral load and liver enzyme levels may be associated with the wild mbl2 aa genotype |
| url | http://dx.doi.org/10.1155/2017/3718451 |
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