Regulatory T Cells in Respiratory Health and Diseases
Respiratory diseases compromise the health of millions of people all over the world and are strongly linked to the immune dysfunction. CD4+FOXP3+ T regulatory cells, also known as Tregs, have a central role maintaining tissue homeostasis during immune responses. Their activity and clinical impact ha...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2019/1907807 |
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| _version_ | 1849407568829480960 |
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| author | Rani Singh Daniel Alape Andrés de Lima Juan Ascanio Adnan Majid Sidhu P. Gangadharan |
| author_facet | Rani Singh Daniel Alape Andrés de Lima Juan Ascanio Adnan Majid Sidhu P. Gangadharan |
| author_sort | Rani Singh |
| collection | DOAJ |
| description | Respiratory diseases compromise the health of millions of people all over the world and are strongly linked to the immune dysfunction. CD4+FOXP3+ T regulatory cells, also known as Tregs, have a central role maintaining tissue homeostasis during immune responses. Their activity and clinical impact have been widely studied in different clinical conditions including autoimmune diseases, inflammatory conditions, and cancer, amongst others. Tregs express transcription factor forkhead box P3 (FOXP3), which allows regulation of the immune response through anti-inflammatory cytokines such as IL-10 or transforming growth factor beta (TGF-β) and direct cell-to-cell interaction. Maintenance of immune tolerance is achieved via modulation of effector CD4+ T helper 1, 2 or 17 (Th1, Th2, Th17) cells by Tregs. This review highlights the recent progress in the understanding of Tregs in different disorders of the respiratory system. |
| format | Article |
| id | doaj-art-48bf965ef5fa47e79e1ac227abf835c4 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-48bf965ef5fa47e79e1ac227abf835c42025-08-20T03:36:01ZengWileyPulmonary Medicine2090-18362090-18442019-01-01201910.1155/2019/19078071907807Regulatory T Cells in Respiratory Health and DiseasesRani Singh0Daniel Alape1Andrés de Lima2Juan Ascanio3Adnan Majid4Sidhu P. Gangadharan5Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USADivision of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USADivision of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USADivision of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USADivision of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USADivision of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USARespiratory diseases compromise the health of millions of people all over the world and are strongly linked to the immune dysfunction. CD4+FOXP3+ T regulatory cells, also known as Tregs, have a central role maintaining tissue homeostasis during immune responses. Their activity and clinical impact have been widely studied in different clinical conditions including autoimmune diseases, inflammatory conditions, and cancer, amongst others. Tregs express transcription factor forkhead box P3 (FOXP3), which allows regulation of the immune response through anti-inflammatory cytokines such as IL-10 or transforming growth factor beta (TGF-β) and direct cell-to-cell interaction. Maintenance of immune tolerance is achieved via modulation of effector CD4+ T helper 1, 2 or 17 (Th1, Th2, Th17) cells by Tregs. This review highlights the recent progress in the understanding of Tregs in different disorders of the respiratory system.http://dx.doi.org/10.1155/2019/1907807 |
| spellingShingle | Rani Singh Daniel Alape Andrés de Lima Juan Ascanio Adnan Majid Sidhu P. Gangadharan Regulatory T Cells in Respiratory Health and Diseases Pulmonary Medicine |
| title | Regulatory T Cells in Respiratory Health and Diseases |
| title_full | Regulatory T Cells in Respiratory Health and Diseases |
| title_fullStr | Regulatory T Cells in Respiratory Health and Diseases |
| title_full_unstemmed | Regulatory T Cells in Respiratory Health and Diseases |
| title_short | Regulatory T Cells in Respiratory Health and Diseases |
| title_sort | regulatory t cells in respiratory health and diseases |
| url | http://dx.doi.org/10.1155/2019/1907807 |
| work_keys_str_mv | AT ranisingh regulatorytcellsinrespiratoryhealthanddiseases AT danielalape regulatorytcellsinrespiratoryhealthanddiseases AT andresdelima regulatorytcellsinrespiratoryhealthanddiseases AT juanascanio regulatorytcellsinrespiratoryhealthanddiseases AT adnanmajid regulatorytcellsinrespiratoryhealthanddiseases AT sidhupgangadharan regulatorytcellsinrespiratoryhealthanddiseases |