Genomic characterization of Leishmania (V.) braziliensis associated with antimony therapeutic failure and variable in vitro tolerance to amphotericin B

Genomic characterization of Leishmania (V.) braziliensis associated with antimony therapeutic failure and variable in vitro tolerance to amphotericin B

Abstract Leishmaniasis, a vector-borne disease caused by protozoa from the Leishmania genus, presents a wide range of clinical manifestations in humans and varying responses to treatments. The main clinical presentations correspond with visceral leishmaniasis (VL), cutaneous leishmaniasis (CL), and...

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Main Authors: Laura Natalia Gonzalez-Garcia, Aura María Rodríguez-Guzmán, Carolina M. Vargas-León, Samanda Aponte, Liliana A. Bonilla-Valbuena, J. Manuel Matiz-González, Ana M Clavijo-Vanegas, Germán Andrés Duarte-Olaya, Catherine Aguilar-Buitrago, Daniel Alfonso Urrea, Jorge Duitama, Maria C. Echeverry
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Leishmania braziliensis
Cutaneous leishmaniasis
Resistance
Amphotericin B
Genome
Biopterin
Online Access:https://doi.org/10.1038/s41598-025-96849-z
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