Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCs
Abstract Exosomes, containing molecular constituents of their cell of origin, including proteins and nucleic acids, were first discovered in immature red blood cells in 1983. Excellent intercell communication can be achieved by shuttling these various molecules between cells. Stem cell-derived exoso...
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| Language: | English |
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BMC
2025-06-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-025-04440-0 |
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| author | Siti Zawiah Abdul Malik Yugashini Muhilan Fazlina Nordin Min Hwei Ng Jia Xian Law Siti A. M. Imran Izyan Mohd Idris Gee Jun Tye |
| author_facet | Siti Zawiah Abdul Malik Yugashini Muhilan Fazlina Nordin Min Hwei Ng Jia Xian Law Siti A. M. Imran Izyan Mohd Idris Gee Jun Tye |
| author_sort | Siti Zawiah Abdul Malik |
| collection | DOAJ |
| description | Abstract Exosomes, containing molecular constituents of their cell of origin, including proteins and nucleic acids, were first discovered in immature red blood cells in 1983. Excellent intercell communication can be achieved by shuttling these various molecules between cells. Stem cell-derived exosomes (SC-Exos) contain paracrine-soluble factors that play important roles in tissue development, homeostasis, and regeneration. This paracrine activity of SC-Exos has been found to be a predominant mechanism by which stem cell-based therapies mediate their effects on degenerative, autoimmune and/or inflammatory diseases. Compared to other types of stem cells, human embryonic stem cells (hESCs), human induced pluripotent stem cells (hiPSCs), human mesenchymal stem cells (hMSCs) are the most popular because of their efficient immunomodulatory effects. The advantages and disadvantages of using exosomes isolated from the stem cell trio for therapeutic applications are further discussed in this review. |
| format | Article |
| id | doaj-art-48bc6ed2038348b088dc4cae48b153ef |
| institution | Kabale University |
| issn | 1757-6512 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-48bc6ed2038348b088dc4cae48b153ef2025-08-20T03:24:25ZengBMCStem Cell Research & Therapy1757-65122025-06-0116111410.1186/s13287-025-04440-0Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCsSiti Zawiah Abdul Malik0Yugashini Muhilan1Fazlina Nordin2Min Hwei Ng3Jia Xian Law4Siti A. M. Imran5Izyan Mohd Idris6Gee Jun Tye7Department of Tissue Engineering and Regenerative Medicine (DTERM), Faculty of Medicine, Universiti Kebangsaan MalaysiaDepartment of Tissue Engineering and Regenerative Medicine (DTERM), Faculty of Medicine, Universiti Kebangsaan MalaysiaDepartment of Tissue Engineering and Regenerative Medicine (DTERM), Faculty of Medicine, Universiti Kebangsaan MalaysiaDepartment of Tissue Engineering and Regenerative Medicine (DTERM), Faculty of Medicine, Universiti Kebangsaan MalaysiaDepartment of Tissue Engineering and Regenerative Medicine (DTERM), Faculty of Medicine, Universiti Kebangsaan MalaysiaMing Medical Sdn. Bhd., Dana 1 Commercial CentreInstitute for Medical Research (IMR), National Institutes of Health (NIH), Ministry of Health MalaysiaMalaysian Institute of Pharmaceuticals and Nutraceuticals, National Institutes of Biotechnology Malaysia, Halaman Bukit GambirAbstract Exosomes, containing molecular constituents of their cell of origin, including proteins and nucleic acids, were first discovered in immature red blood cells in 1983. Excellent intercell communication can be achieved by shuttling these various molecules between cells. Stem cell-derived exosomes (SC-Exos) contain paracrine-soluble factors that play important roles in tissue development, homeostasis, and regeneration. This paracrine activity of SC-Exos has been found to be a predominant mechanism by which stem cell-based therapies mediate their effects on degenerative, autoimmune and/or inflammatory diseases. Compared to other types of stem cells, human embryonic stem cells (hESCs), human induced pluripotent stem cells (hiPSCs), human mesenchymal stem cells (hMSCs) are the most popular because of their efficient immunomodulatory effects. The advantages and disadvantages of using exosomes isolated from the stem cell trio for therapeutic applications are further discussed in this review.https://doi.org/10.1186/s13287-025-04440-0ExosomesStem cellsSC-ExoshMSCshESCsHiPSCs |
| spellingShingle | Siti Zawiah Abdul Malik Yugashini Muhilan Fazlina Nordin Min Hwei Ng Jia Xian Law Siti A. M. Imran Izyan Mohd Idris Gee Jun Tye Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCs Stem Cell Research & Therapy Exosomes Stem cells SC-Exos hMSCs hESCs HiPSCs |
| title | Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCs |
| title_full | Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCs |
| title_fullStr | Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCs |
| title_full_unstemmed | Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCs |
| title_short | Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCs |
| title_sort | stem cell derived exosome trilogy an epic comparison of human mscs escs and ipscs |
| topic | Exosomes Stem cells SC-Exos hMSCs hESCs HiPSCs |
| url | https://doi.org/10.1186/s13287-025-04440-0 |
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