Association between pan-immune-inflammation value and dyslipidemia in the United States population
ObjectTo investigate the possible association between pan-immune-inflammation value (PIV) and dyslipidemia.MethodsThis cross-sectional study used the data obtained from National Health and Nutrition Examination Survey (NHANES). The independent variable used the logarithmic form of PIV-log2 (PIV). Th...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1518304/full |
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| author | Yu Yan Shanshan Jia Xingwei Huo Lu Liu Lirong Sun Lirong Sun Shuangliang Ma Xiaoping Chen |
| author_facet | Yu Yan Shanshan Jia Xingwei Huo Lu Liu Lirong Sun Lirong Sun Shuangliang Ma Xiaoping Chen |
| author_sort | Yu Yan |
| collection | DOAJ |
| description | ObjectTo investigate the possible association between pan-immune-inflammation value (PIV) and dyslipidemia.MethodsThis cross-sectional study used the data obtained from National Health and Nutrition Examination Survey (NHANES). The independent variable used the logarithmic form of PIV-log2 (PIV). The definition of dyslipidemia was based on the National Cholesterol Education Program standards. Weighted multivariate logistic regression analyses, the restricted cubic spline (RCS) and threshold effect analysis were explore the association between PIV and dyslipidemia. Stratified analyses were used to identify potential associations with other covariates. The receiver operating characteristic (ROC) curve was constructed compared to systemic immune-inflammation index (SII).Results6,821 participants were included, of whom 47% were male and 77% had dyslipidemia. After adjusting for all confounders, PIV and dyslipidemia had an significantly positive association (OR (95%CI): 1.13 (1.01-1.25); P = 0.03). Compared to participants with lowest quartile (Q1) of PIV, participants with the highest quartile (Q4) had a significantly higher risk of dyslipidemia (OR (95%CI): 1.37 (1.05-1.80); P = 0.022). The RCS curve showed an inverted J-shaped relationship between PIV and dyslipidemia (P-nonlinear = 0.0415, P-overall < 0.001). The threshold effect analysis revealed that the inflection point was 9.192. Stratified analyses showed that age and BMI modified the PIV-dyslipidemia relationship (P for interaction < 0.05). The ROC curve found that compared with SII, PIV had a similar predictive value (area under curve (AUC): 0.566 vs 0.558; P = 0.073).ConclusionThis study discovered that PIV had a significantly positive relationship with dyslipidemia, especially in young and overweight individuals. |
| format | Article |
| id | doaj-art-48b817bb7f514b12a4c418a5979697c9 |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-48b817bb7f514b12a4c418a5979697c92025-08-20T02:56:31ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-03-011610.3389/fendo.2025.15183041518304Association between pan-immune-inflammation value and dyslipidemia in the United States populationYu Yan0Shanshan Jia1Xingwei Huo2Lu Liu3Lirong Sun4Lirong Sun5Shuangliang Ma6Xiaoping Chen7Department of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Cardiology, Peking University First Hospital, Beijing, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaSecond Department of Internal Medicine, Affiliated Hospital of Tibet University for Nationalities, Xianyang, Shaanxi, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan, ChinaObjectTo investigate the possible association between pan-immune-inflammation value (PIV) and dyslipidemia.MethodsThis cross-sectional study used the data obtained from National Health and Nutrition Examination Survey (NHANES). The independent variable used the logarithmic form of PIV-log2 (PIV). The definition of dyslipidemia was based on the National Cholesterol Education Program standards. Weighted multivariate logistic regression analyses, the restricted cubic spline (RCS) and threshold effect analysis were explore the association between PIV and dyslipidemia. Stratified analyses were used to identify potential associations with other covariates. The receiver operating characteristic (ROC) curve was constructed compared to systemic immune-inflammation index (SII).Results6,821 participants were included, of whom 47% were male and 77% had dyslipidemia. After adjusting for all confounders, PIV and dyslipidemia had an significantly positive association (OR (95%CI): 1.13 (1.01-1.25); P = 0.03). Compared to participants with lowest quartile (Q1) of PIV, participants with the highest quartile (Q4) had a significantly higher risk of dyslipidemia (OR (95%CI): 1.37 (1.05-1.80); P = 0.022). The RCS curve showed an inverted J-shaped relationship between PIV and dyslipidemia (P-nonlinear = 0.0415, P-overall < 0.001). The threshold effect analysis revealed that the inflection point was 9.192. Stratified analyses showed that age and BMI modified the PIV-dyslipidemia relationship (P for interaction < 0.05). The ROC curve found that compared with SII, PIV had a similar predictive value (area under curve (AUC): 0.566 vs 0.558; P = 0.073).ConclusionThis study discovered that PIV had a significantly positive relationship with dyslipidemia, especially in young and overweight individuals.https://www.frontiersin.org/articles/10.3389/fendo.2025.1518304/fullpan-immune-inflammation valuedyslipidemiaNHANESinflammationcross-sectional study |
| spellingShingle | Yu Yan Shanshan Jia Xingwei Huo Lu Liu Lirong Sun Lirong Sun Shuangliang Ma Xiaoping Chen Association between pan-immune-inflammation value and dyslipidemia in the United States population Frontiers in Endocrinology pan-immune-inflammation value dyslipidemia NHANES inflammation cross-sectional study |
| title | Association between pan-immune-inflammation value and dyslipidemia in the United States population |
| title_full | Association between pan-immune-inflammation value and dyslipidemia in the United States population |
| title_fullStr | Association between pan-immune-inflammation value and dyslipidemia in the United States population |
| title_full_unstemmed | Association between pan-immune-inflammation value and dyslipidemia in the United States population |
| title_short | Association between pan-immune-inflammation value and dyslipidemia in the United States population |
| title_sort | association between pan immune inflammation value and dyslipidemia in the united states population |
| topic | pan-immune-inflammation value dyslipidemia NHANES inflammation cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1518304/full |
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