Clinicopathological correlation of adenoid cystic carcinoma: A notorious masquerader and clinical paradox
Background: Adenoid cystic carcinoma (ACC) is an uncommon tumor with nonspecific clinicoradiological features thereby masquerading other nonneoplastic and neoplastic entities. Materials and Methods: Cases of ACC were retrospectively reviewed over a period of 4 years. The clinical details of these pa...
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2018-01-01
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=3;spage=276;epage=281;aulast=Sharma |
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| author | Preeti Sharma Vidya Jha Ashish Kumar Mandal |
| author_facet | Preeti Sharma Vidya Jha Ashish Kumar Mandal |
| author_sort | Preeti Sharma |
| collection | DOAJ |
| description | Background: Adenoid cystic carcinoma (ACC) is an uncommon tumor with nonspecific clinicoradiological features thereby masquerading other nonneoplastic and neoplastic entities. Materials and Methods: Cases of ACC were retrospectively reviewed over a period of 4 years. The clinical details of these patients including fine-needle aspiration cytology (FNAC) and imaging findings were retrieved. Diagnosis was confirmed on histomorphology and supplemented with immunohistochemistry (IHC). Results: Thirty cases of ACC were included in the study. Mean patient age was 55.5 years with a slight female preponderance. Among the 30 ACCs, 10 (33.4%) were located in submandibular gland, 7 (23.4%) in parotid gland, 6 (20%) in sublingual gland, 2 (6.7%) in lung and one each (3.33%) in nasal cavity, breast, cervix, lip, and skin of face. Preoperative imaging was suggestive of malignancy in 29 cases while a single case of parotid gland ACC was misdiagnosed as benign salivary gland neoplasm. FNAC was performed in 29 cases with a diagnostic accuracy of 82.7%. Histopathological examination showed characteristic features of ACC in all cases with perineural invasion seen in 7 cases. On IHC, positivity for cytokeratin was seen in all cases, cluster of differentiation 117 in 24 cases, thyroid transcription factor-1 in two cases and human epidermal growth factor receptor/neu in two cases. All cases were negative for estrogen receptor and progesterone receptor IHC. Mean Ki-67 score was 47.8%. Conclusion: ACCs are notorious tumors showing slow growth kinetics with propensity for perineural invasion, late recurrences, and distant metastasis. It should be kept in mind as a differential diagnosis at unusual sites other than salivary glands. |
| format | Article |
| id | doaj-art-48b7c0098abc40f6bcaae6be2f5a664f |
| institution | OA Journals |
| issn | 0971-5851 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
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| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-48b7c0098abc40f6bcaae6be2f5a664f2025-08-20T02:13:27ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58512018-01-0139327628110.4103/ijmpo.ijmpo_141_16Clinicopathological correlation of adenoid cystic carcinoma: A notorious masquerader and clinical paradoxPreeti SharmaVidya JhaAshish Kumar MandalBackground: Adenoid cystic carcinoma (ACC) is an uncommon tumor with nonspecific clinicoradiological features thereby masquerading other nonneoplastic and neoplastic entities. Materials and Methods: Cases of ACC were retrospectively reviewed over a period of 4 years. The clinical details of these patients including fine-needle aspiration cytology (FNAC) and imaging findings were retrieved. Diagnosis was confirmed on histomorphology and supplemented with immunohistochemistry (IHC). Results: Thirty cases of ACC were included in the study. Mean patient age was 55.5 years with a slight female preponderance. Among the 30 ACCs, 10 (33.4%) were located in submandibular gland, 7 (23.4%) in parotid gland, 6 (20%) in sublingual gland, 2 (6.7%) in lung and one each (3.33%) in nasal cavity, breast, cervix, lip, and skin of face. Preoperative imaging was suggestive of malignancy in 29 cases while a single case of parotid gland ACC was misdiagnosed as benign salivary gland neoplasm. FNAC was performed in 29 cases with a diagnostic accuracy of 82.7%. Histopathological examination showed characteristic features of ACC in all cases with perineural invasion seen in 7 cases. On IHC, positivity for cytokeratin was seen in all cases, cluster of differentiation 117 in 24 cases, thyroid transcription factor-1 in two cases and human epidermal growth factor receptor/neu in two cases. All cases were negative for estrogen receptor and progesterone receptor IHC. Mean Ki-67 score was 47.8%. Conclusion: ACCs are notorious tumors showing slow growth kinetics with propensity for perineural invasion, late recurrences, and distant metastasis. It should be kept in mind as a differential diagnosis at unusual sites other than salivary glands.http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=3;spage=276;epage=281;aulast=SharmaAdenoid cystic carcinomafine-needle aspiration cytologyperineuralsalivary glands |
| spellingShingle | Preeti Sharma Vidya Jha Ashish Kumar Mandal Clinicopathological correlation of adenoid cystic carcinoma: A notorious masquerader and clinical paradox Indian Journal of Medical and Paediatric Oncology Adenoid cystic carcinoma fine-needle aspiration cytology perineural salivary glands |
| title | Clinicopathological correlation of adenoid cystic carcinoma: A notorious masquerader and clinical paradox |
| title_full | Clinicopathological correlation of adenoid cystic carcinoma: A notorious masquerader and clinical paradox |
| title_fullStr | Clinicopathological correlation of adenoid cystic carcinoma: A notorious masquerader and clinical paradox |
| title_full_unstemmed | Clinicopathological correlation of adenoid cystic carcinoma: A notorious masquerader and clinical paradox |
| title_short | Clinicopathological correlation of adenoid cystic carcinoma: A notorious masquerader and clinical paradox |
| title_sort | clinicopathological correlation of adenoid cystic carcinoma a notorious masquerader and clinical paradox |
| topic | Adenoid cystic carcinoma fine-needle aspiration cytology perineural salivary glands |
| url | http://www.ijmpo.org/article.asp?issn=0971-5851;year=2018;volume=39;issue=3;spage=276;epage=281;aulast=Sharma |
| work_keys_str_mv | AT preetisharma clinicopathologicalcorrelationofadenoidcysticcarcinomaanotoriousmasqueraderandclinicalparadox AT vidyajha clinicopathologicalcorrelationofadenoidcysticcarcinomaanotoriousmasqueraderandclinicalparadox AT ashishkumarmandal clinicopathologicalcorrelationofadenoidcysticcarcinomaanotoriousmasqueraderandclinicalparadox |