Iron biomarkers in men with infertility are associated with sperm DNA hydroxymethylation and cumulative live birth rates: a prospective study

Iron biomarkers in men with infertility are associated with sperm DNA hydroxymethylation and cumulative live birth rates: a prospective study

Abstract Background Pregnancy rates after intracytoplasmic sperm injection (ICSI) could be influenced by sperm quality. Maintaining iron homeostasis is crucial for both sperm quality and the activity of ten-eleven translocation (TET) enzymes. TETs play a role in DNA chemical modifications. However,...

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Bibliographic Details
Main Authors: Georges Raad, Fatima Husseiny, Zalihe Yarkiner, Valerie Grandjean, Marwa Bazzi, Marilyne Rizk, Fadi Fakih, Youmna Mourad, Chadi Fakih
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Iron
DNA methylation
Spermatozoa
Infertility
Online Access:https://doi.org/10.1186/s12967-025-06777-9
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