Integrin beta 1 facilitates non-enveloped hepatitis E virus cell entry through the recycling endosome

Integrin beta 1 facilitates non-enveloped hepatitis E virus cell entry through the recycling endosome

Abstract Hepatitis E virus (HEV) is a major cause of acute hepatitis and mainly transmitted faecal-orally. HEV particles present in faeces are naked (nHEV), whereas those found in the blood are quasi-enveloped (eHEV) with a cell-derived lipid membrane. Despite its global health impact, the cellular...

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Main Authors: Rebecca Fu, Paula Jordan, Zoe Engels, Jasmin Alara Weihs, Josias Mürle, Huanting Chi, Sebastian Burbano de Lara, Barbara Helm, Mara Klöhn, Jungen Hu, Andrew Freistaedter, Tobias Boettler, Marco Binder, Ursula Klingmüller, Eike Steinmann, Pierre-Yves Lozach, Thibault Tubiana, Stanley M. Lemon, Viet Loan Dao Thi
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61071-y
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