Non-invasive of liver fibrosis diagnostics: the role of serum markers
Aim of review. The prognosis and management approach for chronic liver diseases of any etiology in many respects are determined by stage and extent of fibrosis which reflects activity, spread and duration of liver disease. Aim of current publication was to highlight these issues.Summary. Investigati...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2015-05-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1000 |
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| author | A. F. Sheptulina Ye. N. Shirokova V. T. Ivashkin |
| author_facet | A. F. Sheptulina Ye. N. Shirokova V. T. Ivashkin |
| author_sort | A. F. Sheptulina |
| collection | DOAJ |
| description | Aim of review. The prognosis and management approach for chronic liver diseases of any etiology in many respects are determined by stage and extent of fibrosis which reflects activity, spread and duration of liver disease. Aim of current publication was to highlight these issues.Summary. Investigations in the field of fibrogenesis processes made possible quantitative estimation of liver fibrosis by non-invasive tests based both on assessment of peripheral blood levels of substances, directly involved in various stages of extracellular matrix synthesis and disintegration, and on the routine laboratory tests reflecting activity of inflammation, degree of disorder of synthetic liver function and fibrosis progression.Conclusion. Study of diagnostic accuracy of serum markers for assessment of fibrosis stage in liver disea ses of various etiology will provide development of comprehensive non-invasive test for estimation of treatment response rate, course and progression rate of disease |
| format | Article |
| id | doaj-art-48a783e4426544e690b1076a84cb0bfd |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2015-05-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-48a783e4426544e690b1076a84cb0bfd2025-02-10T16:14:33ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732015-05-012522840608Non-invasive of liver fibrosis diagnostics: the role of serum markersA. F. Sheptulina0Ye. N. Shirokova1V. T. Ivashkin2State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationAim of review. The prognosis and management approach for chronic liver diseases of any etiology in many respects are determined by stage and extent of fibrosis which reflects activity, spread and duration of liver disease. Aim of current publication was to highlight these issues.Summary. Investigations in the field of fibrogenesis processes made possible quantitative estimation of liver fibrosis by non-invasive tests based both on assessment of peripheral blood levels of substances, directly involved in various stages of extracellular matrix synthesis and disintegration, and on the routine laboratory tests reflecting activity of inflammation, degree of disorder of synthetic liver function and fibrosis progression.Conclusion. Study of diagnostic accuracy of serum markers for assessment of fibrosis stage in liver disea ses of various etiology will provide development of comprehensive non-invasive test for estimation of treatment response rate, course and progression rate of diseasehttps://www.gastro-j.ru/jour/article/view/1000liver fibrosisbiopsyindirect serum markers of fibrosisdirect serum markers of fibrosis |
| spellingShingle | A. F. Sheptulina Ye. N. Shirokova V. T. Ivashkin Non-invasive of liver fibrosis diagnostics: the role of serum markers Российский журнал гастроэнтерологии, гепатологии, колопроктологии liver fibrosis biopsy indirect serum markers of fibrosis direct serum markers of fibrosis |
| title | Non-invasive of liver fibrosis diagnostics: the role of serum markers |
| title_full | Non-invasive of liver fibrosis diagnostics: the role of serum markers |
| title_fullStr | Non-invasive of liver fibrosis diagnostics: the role of serum markers |
| title_full_unstemmed | Non-invasive of liver fibrosis diagnostics: the role of serum markers |
| title_short | Non-invasive of liver fibrosis diagnostics: the role of serum markers |
| title_sort | non invasive of liver fibrosis diagnostics the role of serum markers |
| topic | liver fibrosis biopsy indirect serum markers of fibrosis direct serum markers of fibrosis |
| url | https://www.gastro-j.ru/jour/article/view/1000 |
| work_keys_str_mv | AT afsheptulina noninvasiveofliverfibrosisdiagnosticstheroleofserummarkers AT yenshirokova noninvasiveofliverfibrosisdiagnosticstheroleofserummarkers AT vtivashkin noninvasiveofliverfibrosisdiagnosticstheroleofserummarkers |