The role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after COVID-19 infection
Introduction. The new coronavirus infection (COVID-19) is one of the most important problems in modern medicine. One of the etiopathogenetic COVID-19 arms is presented by a disorder in the hemostasis system, which can be associated with emerging thrombosis of various localizations and altered vascul...
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Sankt-Peterburg : NIIÈM imeni Pastera
2025-07-01
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| Series: | Инфекция и иммунитет |
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| Online Access: | https://iimmun.ru/iimm/article/viewFile/17816/2179 |
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| author | O. A Perevezentsev I. S. Mamedov D. V. Burtsev |
| author_facet | O. A Perevezentsev I. S. Mamedov D. V. Burtsev |
| author_sort | O. A Perevezentsev |
| collection | DOAJ |
| description | Introduction. The new coronavirus infection (COVID-19) is one of the most important problems in modern medicine. One of the etiopathogenetic COVID-19 arms is presented by a disorder in the hemostasis system, which can be associated with emerging thrombosis of various localizations and altered vascular circulation in small vessels. But coagulation disorders can be pathogenetically associated with atherosclerotic processes in the vascular bed, which can be activated as early as at age of 35–40 years. Therefore, it is relevant to study the genetic factors between COVID-19 etiopathogenetic relation and thrombogenic and atherosclerotic pathological processes. Purpose of the study. To establish a relation between previous COVID-19 infection and risk of venous thrombosis caused by 8 genetic variants ((F2 20210GA, F5 1691GA, F7 10976GA, F13 GT, ITGA2 807CT, ITGB3 1565 TC, PAI-1 -675 5G4G) in the coagulation system genes in patients with atherosclerosis. Materials and methods. The study included 172 patients aged 30 to 55 years with signs of atherogenic vascular lesions, who had episodes of venous thrombosis of various localizations within a year after clinically manifested COVID-19, confirmed by molecular genetic diagnostics of SARS-CoV-2, and 151 COVID-19 convalescent patients aged 30 to 54 years (comparison group), without episodes of venous thrombosis. Molecular genetic analysis of genetic variants of the hemostasis system genes was performed by real-time PCR with automated melting curve analysis. Results. According to the results of the association analysis of genetic variants with venous thrombosis in COVID-19 convalescent patients, a relation was established for 2 genetic variants, ITGA2 807CT (TT OR = 5.59 (СI: 2.86–10.93, p 0.001)) and ITGB3 1565 TC (genotype CC, OR = 6.55 (СI: 2.23–19.22, p 0.001)). Conclusion. Thus, we established an association between 2 genetic variants (ITGA2 807CT and ITGB3 1565 TC) and venous thrombosis in COVID-19 convalescent patients with atherosclerosis. |
| format | Article |
| id | doaj-art-48a35cf6c9774f3a9a4dbfa33159259f |
| institution | DOAJ |
| issn | 2220-7619 2313-7398 |
| language | Russian |
| publishDate | 2025-07-01 |
| publisher | Sankt-Peterburg : NIIÈM imeni Pastera |
| record_format | Article |
| series | Инфекция и иммунитет |
| spelling | doaj-art-48a35cf6c9774f3a9a4dbfa33159259f2025-08-20T02:56:30ZrusSankt-Peterburg : NIIÈM imeni PasteraИнфекция и иммунитет2220-76192313-73982025-07-0115237838210.15789/2220-7619-TRO-178161529The role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after COVID-19 infectionO. A Perevezentsev0I. S. Mamedov1D. V. Burtsev2Rostov State Medical UniversityScientific and Practical Center for Specialized Medical Care for children named after V.F. Voyno-Yasenetsky Department of Health of the City of MosсowRostov State Medical UniversityIntroduction. The new coronavirus infection (COVID-19) is one of the most important problems in modern medicine. One of the etiopathogenetic COVID-19 arms is presented by a disorder in the hemostasis system, which can be associated with emerging thrombosis of various localizations and altered vascular circulation in small vessels. But coagulation disorders can be pathogenetically associated with atherosclerotic processes in the vascular bed, which can be activated as early as at age of 35–40 years. Therefore, it is relevant to study the genetic factors between COVID-19 etiopathogenetic relation and thrombogenic and atherosclerotic pathological processes. Purpose of the study. To establish a relation between previous COVID-19 infection and risk of venous thrombosis caused by 8 genetic variants ((F2 20210GA, F5 1691GA, F7 10976GA, F13 GT, ITGA2 807CT, ITGB3 1565 TC, PAI-1 -675 5G4G) in the coagulation system genes in patients with atherosclerosis. Materials and methods. The study included 172 patients aged 30 to 55 years with signs of atherogenic vascular lesions, who had episodes of venous thrombosis of various localizations within a year after clinically manifested COVID-19, confirmed by molecular genetic diagnostics of SARS-CoV-2, and 151 COVID-19 convalescent patients aged 30 to 54 years (comparison group), without episodes of venous thrombosis. Molecular genetic analysis of genetic variants of the hemostasis system genes was performed by real-time PCR with automated melting curve analysis. Results. According to the results of the association analysis of genetic variants with venous thrombosis in COVID-19 convalescent patients, a relation was established for 2 genetic variants, ITGA2 807CT (TT OR = 5.59 (СI: 2.86–10.93, p 0.001)) and ITGB3 1565 TC (genotype CC, OR = 6.55 (СI: 2.23–19.22, p 0.001)). Conclusion. Thus, we established an association between 2 genetic variants (ITGA2 807CT and ITGB3 1565 TC) and venous thrombosis in COVID-19 convalescent patients with atherosclerosis.https://iimmun.ru/iimm/article/viewFile/17816/2179covid-19atherosclerosisthrombosisgenetic variantfactor leidenprothrombin |
| spellingShingle | O. A Perevezentsev I. S. Mamedov D. V. Burtsev The role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after COVID-19 infection Инфекция и иммунитет covid-19 atherosclerosis thrombosis genetic variant factor leiden prothrombin |
| title | The role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after COVID-19 infection |
| title_full | The role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after COVID-19 infection |
| title_fullStr | The role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after COVID-19 infection |
| title_full_unstemmed | The role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after COVID-19 infection |
| title_short | The role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after COVID-19 infection |
| title_sort | role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after covid 19 infection |
| topic | covid-19 atherosclerosis thrombosis genetic variant factor leiden prothrombin |
| url | https://iimmun.ru/iimm/article/viewFile/17816/2179 |
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