Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer Therapies
In recent decades, immunotherapy has been considered a promising treatment approach. The modulatable enhancement or attenuation of the body’s immune response can effectively suppress tumors. However, challenges persist in clinical applications due to the lack of precision in antigen presentation to...
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MDPI AG
2024-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/9/1057 |
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| author | Bin Gu Qin Zhao Yiran Ao |
| author_facet | Bin Gu Qin Zhao Yiran Ao |
| author_sort | Bin Gu |
| collection | DOAJ |
| description | In recent decades, immunotherapy has been considered a promising treatment approach. The modulatable enhancement or attenuation of the body’s immune response can effectively suppress tumors. However, challenges persist in clinical applications due to the lack of precision in antigen presentation to immune cells, immune escape mechanisms, and immunotherapy-mediated side effects. As a potential delivery system for drugs and immunomodulators, mesoporous silica has attracted extensive attention recently. Mesoporous silica nanoparticles (MSNs) possess high porosity, a large specific surface area, excellent biocompatibility, and facile surface modifiability, making them suitable as multifunctional carriers in immunotherapy. This article summarizes the latest advancements in the application of MSNs as carriers in cancer immunotherapy, aiming to stimulate further exploration of the immunomodulatory mechanisms and the development of immunotherapeutics based on MSNs. |
| format | Article |
| id | doaj-art-489ebb4484004e93b1cd97a756cc139c |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-489ebb4484004e93b1cd97a756cc139c2025-08-20T01:56:00ZengMDPI AGBiomolecules2218-273X2024-08-01149105710.3390/biom14091057Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer TherapiesBin Gu0Qin Zhao1Yiran Ao2State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Bio-Medicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Bio-Medicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Bio-Medicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, ChinaIn recent decades, immunotherapy has been considered a promising treatment approach. The modulatable enhancement or attenuation of the body’s immune response can effectively suppress tumors. However, challenges persist in clinical applications due to the lack of precision in antigen presentation to immune cells, immune escape mechanisms, and immunotherapy-mediated side effects. As a potential delivery system for drugs and immunomodulators, mesoporous silica has attracted extensive attention recently. Mesoporous silica nanoparticles (MSNs) possess high porosity, a large specific surface area, excellent biocompatibility, and facile surface modifiability, making them suitable as multifunctional carriers in immunotherapy. This article summarizes the latest advancements in the application of MSNs as carriers in cancer immunotherapy, aiming to stimulate further exploration of the immunomodulatory mechanisms and the development of immunotherapeutics based on MSNs.https://www.mdpi.com/2218-273X/14/9/1057nanoparticlescancerimmunotherapyMSNcombined anti-tumor therapy |
| spellingShingle | Bin Gu Qin Zhao Yiran Ao Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer Therapies Biomolecules nanoparticles cancer immunotherapy MSN combined anti-tumor therapy |
| title | Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer Therapies |
| title_full | Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer Therapies |
| title_fullStr | Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer Therapies |
| title_full_unstemmed | Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer Therapies |
| title_short | Advances in Immunomodulatory Mesoporous Silica Nanoparticles for Inflammatory and Cancer Therapies |
| title_sort | advances in immunomodulatory mesoporous silica nanoparticles for inflammatory and cancer therapies |
| topic | nanoparticles cancer immunotherapy MSN combined anti-tumor therapy |
| url | https://www.mdpi.com/2218-273X/14/9/1057 |
| work_keys_str_mv | AT bingu advancesinimmunomodulatorymesoporoussilicananoparticlesforinflammatoryandcancertherapies AT qinzhao advancesinimmunomodulatorymesoporoussilicananoparticlesforinflammatoryandcancertherapies AT yiranao advancesinimmunomodulatorymesoporoussilicananoparticlesforinflammatoryandcancertherapies |