CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer.

CD4+CD25+FOXP3+ regulatory T cells suppress anti-tumor immune responses in patients with colorectal cancer.

<h4>Background</h4>A wealth of evidence obtained using mouse models indicates that CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) maintain peripheral tolerance to self-antigens and also inhibit anti-tumor immune responses. To date there is limited information about CD4(+) T cell respons...

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Bibliographic Details
Main Authors: Sarah L Clarke, Gareth J Betts, Andrea Plant, Kate L Wright, Tariq M El-Shanawany, Richard Harrop, Jared Torkington, Brian I Rees, Geraint T Williams, Awen M Gallimore, Andrew J Godkin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2006-12-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0000129&type=printable
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