The association between aggregate index of systemic inflammation and DXA-measured body composition parameters in adolescents
BackgroundSystemic inflammation during adolescence may critically influence metabolic and musculoskeletal health, yet comprehensive biomarkers predicting adverse body composition remain underexplored. The aggregate index of systemic inflammation (AISI), integrating neutrophils, platelets, monocytes,...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-06-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1612735/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849333773065256960 |
|---|---|
| author | Haihua Wang Luping Tao Zhongxin Zhu |
| author_facet | Haihua Wang Luping Tao Zhongxin Zhu |
| author_sort | Haihua Wang |
| collection | DOAJ |
| description | BackgroundSystemic inflammation during adolescence may critically influence metabolic and musculoskeletal health, yet comprehensive biomarkers predicting adverse body composition remain underexplored. The aggregate index of systemic inflammation (AISI), integrating neutrophils, platelets, monocytes, and lymphocytes, offers a novel metric to assess this relationship.MethodsThis cross-sectional study analyzed 3,661 adolescents (aged 12–19 years) from NHANES 2011–2018. AISI was calculated from complete blood counts, and body composition parameters—appendicular lean mass index (ALMI), visceral adipose tissue area (VATA), and total bone mineral density (BMD)—were measured via dual-energy X-ray absorptiometry (DXA). Multivariable linear regression and threshold effect models evaluated associations, adjusting for demographic, metabolic, and lifestyle covariates.ResultsHigher logAISI was associated with lower ALMI (β = −0.189, 95% CI: −0.262 to −0.116), greater VATA (β = 3.017, 1.266–4.769), and reduced BMD (β = −0.017, −0.027 to −0.007). A threshold effect emerged at logAISI = 2.2, beyond which inflammation’s impact on VATA and BMD intensified.ConclusionElevated AISI correlates with adverse body composition in adolescents. The identified threshold suggests a potential clinical benchmark for early intervention. These findings underscore systemic inflammation as a modifiable target to mitigate metabolic and musculoskeletal risks during this critical developmental period. |
| format | Article |
| id | doaj-art-48949aa6028946eeb2bad2c97c362db4 |
| institution | Kabale University |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-48949aa6028946eeb2bad2c97c362db42025-08-20T03:45:45ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-06-011610.3389/fphys.2025.16127351612735The association between aggregate index of systemic inflammation and DXA-measured body composition parameters in adolescentsHaihua Wang0Luping Tao1Zhongxin Zhu2Department of Hospital Management, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, ChinaDepartment of Clinical Research Center, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, ChinaDepartment of Clinical Research Center, The First People’s Hospital of Xiaoshan District, Xiaoshan Affiliated Hospital of Wenzhou Medical University, Hangzhou, Zhejiang, ChinaBackgroundSystemic inflammation during adolescence may critically influence metabolic and musculoskeletal health, yet comprehensive biomarkers predicting adverse body composition remain underexplored. The aggregate index of systemic inflammation (AISI), integrating neutrophils, platelets, monocytes, and lymphocytes, offers a novel metric to assess this relationship.MethodsThis cross-sectional study analyzed 3,661 adolescents (aged 12–19 years) from NHANES 2011–2018. AISI was calculated from complete blood counts, and body composition parameters—appendicular lean mass index (ALMI), visceral adipose tissue area (VATA), and total bone mineral density (BMD)—were measured via dual-energy X-ray absorptiometry (DXA). Multivariable linear regression and threshold effect models evaluated associations, adjusting for demographic, metabolic, and lifestyle covariates.ResultsHigher logAISI was associated with lower ALMI (β = −0.189, 95% CI: −0.262 to −0.116), greater VATA (β = 3.017, 1.266–4.769), and reduced BMD (β = −0.017, −0.027 to −0.007). A threshold effect emerged at logAISI = 2.2, beyond which inflammation’s impact on VATA and BMD intensified.ConclusionElevated AISI correlates with adverse body composition in adolescents. The identified threshold suggests a potential clinical benchmark for early intervention. These findings underscore systemic inflammation as a modifiable target to mitigate metabolic and musculoskeletal risks during this critical developmental period.https://www.frontiersin.org/articles/10.3389/fphys.2025.1612735/fullsystemic inflammationadolescentsbody compositionmuscle massvisceral adipositybone density |
| spellingShingle | Haihua Wang Luping Tao Zhongxin Zhu The association between aggregate index of systemic inflammation and DXA-measured body composition parameters in adolescents Frontiers in Physiology systemic inflammation adolescents body composition muscle mass visceral adiposity bone density |
| title | The association between aggregate index of systemic inflammation and DXA-measured body composition parameters in adolescents |
| title_full | The association between aggregate index of systemic inflammation and DXA-measured body composition parameters in adolescents |
| title_fullStr | The association between aggregate index of systemic inflammation and DXA-measured body composition parameters in adolescents |
| title_full_unstemmed | The association between aggregate index of systemic inflammation and DXA-measured body composition parameters in adolescents |
| title_short | The association between aggregate index of systemic inflammation and DXA-measured body composition parameters in adolescents |
| title_sort | association between aggregate index of systemic inflammation and dxa measured body composition parameters in adolescents |
| topic | systemic inflammation adolescents body composition muscle mass visceral adiposity bone density |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1612735/full |
| work_keys_str_mv | AT haihuawang theassociationbetweenaggregateindexofsystemicinflammationanddxameasuredbodycompositionparametersinadolescents AT lupingtao theassociationbetweenaggregateindexofsystemicinflammationanddxameasuredbodycompositionparametersinadolescents AT zhongxinzhu theassociationbetweenaggregateindexofsystemicinflammationanddxameasuredbodycompositionparametersinadolescents AT haihuawang associationbetweenaggregateindexofsystemicinflammationanddxameasuredbodycompositionparametersinadolescents AT lupingtao associationbetweenaggregateindexofsystemicinflammationanddxameasuredbodycompositionparametersinadolescents AT zhongxinzhu associationbetweenaggregateindexofsystemicinflammationanddxameasuredbodycompositionparametersinadolescents |