Contraceptive Potential of Methanol Leaf Extract of Ananas comosus In Female Wistar Rats
Background: Traditionally, Ananas comosus leaf is used locally to prevent pregnancy among the indians. Objective: To investigate the effect of Ananas comosus methanol leaf extract on oestrus cycle and ovulation. Study Design: The study was conducted using 20 mature female rats with regular oest...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nigerian Medical Association, Akwa Ibom State Branch
2025-04-01
|
| Series: | Ibom Medical Journal |
| Subjects: | |
| Online Access: | http://ibommedicaljournal.org/index.php/imjhome/article/view/674 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850104729129975808 |
|---|---|
| author | Johnson EI Ekanem AU Bassey E Nwafor P |
| author_facet | Johnson EI Ekanem AU Bassey E Nwafor P |
| author_sort | Johnson EI |
| collection | DOAJ |
| description |
Background: Traditionally, Ananas comosus leaf is used locally to prevent pregnancy among the indians.
Objective: To investigate the effect of Ananas comosus methanol leaf extract on oestrus cycle and ovulation.
Study Design: The study was conducted using 20 mature female rats with regular oestrus cycle. The three experimental groups of 5 animals each received a stat dose of 485.5mg/kg, 970 mg/kg and 1455.5 mg/kg body weight respectively while the control group received 1ml of normal saline. Doses were gotten from LD50. All administrations were done intraperitoneally at proestrus and vaginal smear were examined for 8 days to investigate the effects of the extract on oestrus cycle and ovulation.
Result: Ovulation was prevented, oestrus cycle disrupted with prolongation of the dioestrus phases and number of mature follicles reduced on ovary histology.
Conclusion: The study showed that Ananas comosus methanol leaf extract prevented ovulation from occurring and caused irregularity of the oestrus cycle with the disruption of fertility hormones.
|
| format | Article |
| id | doaj-art-488fb85ac1b842ff96d64fb4b6bda955 |
| institution | DOAJ |
| issn | 1597-7188 2735-9964 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nigerian Medical Association, Akwa Ibom State Branch |
| record_format | Article |
| series | Ibom Medical Journal |
| spelling | doaj-art-488fb85ac1b842ff96d64fb4b6bda9552025-08-20T02:39:16ZengNigerian Medical Association, Akwa Ibom State BranchIbom Medical Journal1597-71882735-99642025-04-0118210.61386/imj.v18i2.674Contraceptive Potential of Methanol Leaf Extract of Ananas comosus In Female Wistar RatsJohnson EI0Ekanem AU1Bassey E2Nwafor P3Department of Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Uyo, Uyo, Akwa Ibom State, NigeriaDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Uyo, Uyo, Akwa Ibom State, NigeriaDepartment of Anatomy, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Uyo, Uyo, Akwa Ibom State, NigeriaDepartment of Pharmacology, Department of Pharmacology, Rivers State University, Rivers State, Nigeria Background: Traditionally, Ananas comosus leaf is used locally to prevent pregnancy among the indians. Objective: To investigate the effect of Ananas comosus methanol leaf extract on oestrus cycle and ovulation. Study Design: The study was conducted using 20 mature female rats with regular oestrus cycle. The three experimental groups of 5 animals each received a stat dose of 485.5mg/kg, 970 mg/kg and 1455.5 mg/kg body weight respectively while the control group received 1ml of normal saline. Doses were gotten from LD50. All administrations were done intraperitoneally at proestrus and vaginal smear were examined for 8 days to investigate the effects of the extract on oestrus cycle and ovulation. Result: Ovulation was prevented, oestrus cycle disrupted with prolongation of the dioestrus phases and number of mature follicles reduced on ovary histology. Conclusion: The study showed that Ananas comosus methanol leaf extract prevented ovulation from occurring and caused irregularity of the oestrus cycle with the disruption of fertility hormones. http://ibommedicaljournal.org/index.php/imjhome/article/view/674Ananas comosus leafovaryoestrus cyclecontraceptivepregnancyovulation |
| spellingShingle | Johnson EI Ekanem AU Bassey E Nwafor P Contraceptive Potential of Methanol Leaf Extract of Ananas comosus In Female Wistar Rats Ibom Medical Journal Ananas comosus leaf ovary oestrus cycle contraceptive pregnancy ovulation |
| title | Contraceptive Potential of Methanol Leaf Extract of Ananas comosus In Female Wistar Rats |
| title_full | Contraceptive Potential of Methanol Leaf Extract of Ananas comosus In Female Wistar Rats |
| title_fullStr | Contraceptive Potential of Methanol Leaf Extract of Ananas comosus In Female Wistar Rats |
| title_full_unstemmed | Contraceptive Potential of Methanol Leaf Extract of Ananas comosus In Female Wistar Rats |
| title_short | Contraceptive Potential of Methanol Leaf Extract of Ananas comosus In Female Wistar Rats |
| title_sort | contraceptive potential of methanol leaf extract of ananas comosus in female wistar rats |
| topic | Ananas comosus leaf ovary oestrus cycle contraceptive pregnancy ovulation |
| url | http://ibommedicaljournal.org/index.php/imjhome/article/view/674 |
| work_keys_str_mv | AT johnsonei contraceptivepotentialofmethanolleafextractofananascomosusinfemalewistarrats AT ekanemau contraceptivepotentialofmethanolleafextractofananascomosusinfemalewistarrats AT basseye contraceptivepotentialofmethanolleafextractofananascomosusinfemalewistarrats AT nwaforp contraceptivepotentialofmethanolleafextractofananascomosusinfemalewistarrats |