Contraceptive Potential of Methanol Leaf Extract of Ananas comosus In Female Wistar Rats
Background: Traditionally, Ananas comosus leaf is used locally to prevent pregnancy among the indians. Objective: To investigate the effect of Ananas comosus methanol leaf extract on oestrus cycle and ovulation. Study Design: The study was conducted using 20 mature female rats with regular oest...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nigerian Medical Association, Akwa Ibom State Branch
2025-04-01
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| Series: | Ibom Medical Journal |
| Subjects: | |
| Online Access: | http://ibommedicaljournal.org/index.php/imjhome/article/view/674 |
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| Summary: | Background: Traditionally, Ananas comosus leaf is used locally to prevent pregnancy among the indians.
Objective: To investigate the effect of Ananas comosus methanol leaf extract on oestrus cycle and ovulation.
Study Design: The study was conducted using 20 mature female rats with regular oestrus cycle. The three experimental groups of 5 animals each received a stat dose of 485.5mg/kg, 970 mg/kg and 1455.5 mg/kg body weight respectively while the control group received 1ml of normal saline. Doses were gotten from LD50. All administrations were done intraperitoneally at proestrus and vaginal smear were examined for 8 days to investigate the effects of the extract on oestrus cycle and ovulation.
Result: Ovulation was prevented, oestrus cycle disrupted with prolongation of the dioestrus phases and number of mature follicles reduced on ovary histology.
Conclusion: The study showed that Ananas comosus methanol leaf extract prevented ovulation from occurring and caused irregularity of the oestrus cycle with the disruption of fertility hormones.
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| ISSN: | 1597-7188 2735-9964 |