Comprehensive microarray analysis for the identification of therapeutic targets within HIF-1α signalling networks in diet-induced obesity via hypothalamic inflammation

Comprehensive microarray analysis for the identification of therapeutic targets within HIF-1α signalling networks in diet-induced obesity via hypothalamic inflammation

ABSTRACT Objective: A high-fat diet (HFD) significantly contributes to obesity and alters the neurological function of the brain. This study explored the influence of hypoxia-inducible factor (HIF-1) and its downstream molecules on obesity progression in the context of HFD-induced hypothalamic infl...

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Main Authors: Hai Guo, Lijuan Ma, Dilihumaier Duolikun, Qiaoling Yao
Format: Article
Language:English
Published: Brazilian Society of Endocrinology and Metabolism 2025-03-01
Series:Archives of Endocrinology and Metabolism
Subjects:
Diet-induced obesity
hypoxia-inducible factor (HIF)-1α
immune infiltration
hypothalamus
ksr2
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000101102&tlng=en
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