Summary of 16-Year Observation of Reflux Esophagitis-Like Symptoms in A Natural Village in A High-Incidence Area of Esophageal Cancer
ObjectiveTo investigate the screening results and factors affecting abnormal detection rates among high-risk groups of esophageal cancer and to explore effective intervention measures. MethodsWe investigated and collected the information on gender, education level, age, marital status, symptoms of r...
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Magazine House of Cancer Research on Prevention and Treatment
2025-06-01
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| Series: | Zhongliu Fangzhi Yanjiu |
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| Online Access: | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1290 |
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| author | Junqing LIU Lingling LEI Yaru FU Xin SONG Jingjing WANG Xueke ZHAO Min LIU Zongmin FAN Fangzhou DAI Xuena HAN Zhuo YANG Kan ZHONG Sai YANG Qiang ZHANG Qide BAO Lidong WANG |
| author_facet | Junqing LIU Lingling LEI Yaru FU Xin SONG Jingjing WANG Xueke ZHAO Min LIU Zongmin FAN Fangzhou DAI Xuena HAN Zhuo YANG Kan ZHONG Sai YANG Qiang ZHANG Qide BAO Lidong WANG |
| author_sort | Junqing LIU |
| collection | DOAJ |
| description | ObjectiveTo investigate the screening results and factors affecting abnormal detection rates among high-risk groups of esophageal cancer and to explore effective intervention measures. MethodsWe investigated and collected the information on gender, education level, age, marital status, symptoms of reflux esophagitis (heartburn, acid reflux, belching, hiccup, foreign body sensation in the pharynx, and difficulty swallowing), consumption of pickled vegetables, salt use, and esophageal cancer incidence of villagers in a natural village in Wenfeng District, Anyang City, Henan Province. Changes in reflux esophagitis symptoms in the high-incidence area of esophageal cancer before and after 16 years were observed, and the relationship of such changes with esophageal cancer was analyzed. ResultsIn 2008, 711 cases were epidemiologically investigated, including 213 cases with one of the symptoms of reflux esophagitis such as heartburn, acid reflux, belching, hiccups, foreign body sensation in the pharynx, and difficulty swallowing (sorted in accordance with the abovementioned symptoms; if there are multiple symptoms, then the former is taken); 55 cases with at least two related symptoms, among which the most symptom was heartburn in 108 cases (15.1%); followed by acid reflux, belching, etc. In 2024, the same group of people was investigated, and eight people were missing because of relocation. A total of 703 people were successfully investigated, of which 189 cases (26.8%) had one of the symptoms of reflux esophagitis, such as heartburn (sorted in accordance with relevant symptoms, if there are multiple symptoms, then the former will be selected); 167 cases (23.7%) had at least two related symptoms, among which the most symptom was heartburn in 139 cases (19.7%); followed by acid reflux. Over 16 years, among the 703 people investigated, 45 cases had esophageal cancer and they had one or more of the abovementioned symptoms. No significant differences in the reflux esophagitis-like symptoms were found between 2008 and 2024 (P=0.26); no significant differences in the composition of reflux esophagitis-like symptoms were found between 2008 and 2024 (P=0.299). ConclusionThe detection rate of reflux esophagitis-related symptoms in the population in a high-risk area of esophageal cancer has not decreased in the past 16 years, and the high-risk factors still exist. Esophageal cancer is closely related to reflux esophagitis, and clinical practice can provide early diagnosis and treatment for high-risk population. |
| format | Article |
| id | doaj-art-4888d199508f4ed7a6c78e5d1bd93c74 |
| institution | Kabale University |
| issn | 1000-8578 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj-art-4888d199508f4ed7a6c78e5d1bd93c742025-08-20T03:32:24ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782025-06-0152646146510.3971/j.issn.1000-8578.2025.24.129020241290Summary of 16-Year Observation of Reflux Esophagitis-Like Symptoms in A Natural Village in A High-Incidence Area of Esophageal CancerJunqing LIU0Lingling LEI1Yaru FU2Xin SONG3Jingjing WANG4Xueke ZHAO5Min LIU6Zongmin FAN7Fangzhou DAI8Xuena HAN9Zhuo YANG10Kan ZHONG11Sai YANG12Qiang ZHANG13Qide BAO14Lidong WANG15Department of Oncology, Anyang Regional Hospital, Anyang 455000, ChinaDepartment of Oncology, Anyang Regional Hospital, Anyang 455000, ChinaDepartment of Oncology, Anyang Regional Hospital, Anyang 455000, ChinaHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Oncology, Anyang Regional Hospital, Anyang 455000, ChinaHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Oncology, Anyang Regional Hospital, Anyang 455000, ChinaHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Oncology, Anyang Regional Hospital, Anyang 455000, ChinaHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Oncology, Anyang Regional Hospital, Anyang 455000, ChinaHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaDepartment of Oncology, Anyang Regional Hospital, Anyang 455000, ChinaDepartment of Oncology, Anyang Regional Hospital, Anyang 455000, ChinaDepartment of Oncology, Anyang Regional Hospital, Anyang 455000, ChinaHenan Key Laboratory for Esophageal Cancer Research and National Key Laboratory of Metabolism Disorder and Esophageal Cancer Prevention & Treatment of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, ChinaObjectiveTo investigate the screening results and factors affecting abnormal detection rates among high-risk groups of esophageal cancer and to explore effective intervention measures. MethodsWe investigated and collected the information on gender, education level, age, marital status, symptoms of reflux esophagitis (heartburn, acid reflux, belching, hiccup, foreign body sensation in the pharynx, and difficulty swallowing), consumption of pickled vegetables, salt use, and esophageal cancer incidence of villagers in a natural village in Wenfeng District, Anyang City, Henan Province. Changes in reflux esophagitis symptoms in the high-incidence area of esophageal cancer before and after 16 years were observed, and the relationship of such changes with esophageal cancer was analyzed. ResultsIn 2008, 711 cases were epidemiologically investigated, including 213 cases with one of the symptoms of reflux esophagitis such as heartburn, acid reflux, belching, hiccups, foreign body sensation in the pharynx, and difficulty swallowing (sorted in accordance with the abovementioned symptoms; if there are multiple symptoms, then the former is taken); 55 cases with at least two related symptoms, among which the most symptom was heartburn in 108 cases (15.1%); followed by acid reflux, belching, etc. In 2024, the same group of people was investigated, and eight people were missing because of relocation. A total of 703 people were successfully investigated, of which 189 cases (26.8%) had one of the symptoms of reflux esophagitis, such as heartburn (sorted in accordance with relevant symptoms, if there are multiple symptoms, then the former will be selected); 167 cases (23.7%) had at least two related symptoms, among which the most symptom was heartburn in 139 cases (19.7%); followed by acid reflux. Over 16 years, among the 703 people investigated, 45 cases had esophageal cancer and they had one or more of the abovementioned symptoms. No significant differences in the reflux esophagitis-like symptoms were found between 2008 and 2024 (P=0.26); no significant differences in the composition of reflux esophagitis-like symptoms were found between 2008 and 2024 (P=0.299). ConclusionThe detection rate of reflux esophagitis-related symptoms in the population in a high-risk area of esophageal cancer has not decreased in the past 16 years, and the high-risk factors still exist. Esophageal cancer is closely related to reflux esophagitis, and clinical practice can provide early diagnosis and treatment for high-risk population.http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1290esophageal cancerhigh-incidence areareflux esophagitisepidemiological survey |
| spellingShingle | Junqing LIU Lingling LEI Yaru FU Xin SONG Jingjing WANG Xueke ZHAO Min LIU Zongmin FAN Fangzhou DAI Xuena HAN Zhuo YANG Kan ZHONG Sai YANG Qiang ZHANG Qide BAO Lidong WANG Summary of 16-Year Observation of Reflux Esophagitis-Like Symptoms in A Natural Village in A High-Incidence Area of Esophageal Cancer Zhongliu Fangzhi Yanjiu esophageal cancer high-incidence area reflux esophagitis epidemiological survey |
| title | Summary of 16-Year Observation of Reflux Esophagitis-Like Symptoms in A Natural Village in A High-Incidence Area of Esophageal Cancer |
| title_full | Summary of 16-Year Observation of Reflux Esophagitis-Like Symptoms in A Natural Village in A High-Incidence Area of Esophageal Cancer |
| title_fullStr | Summary of 16-Year Observation of Reflux Esophagitis-Like Symptoms in A Natural Village in A High-Incidence Area of Esophageal Cancer |
| title_full_unstemmed | Summary of 16-Year Observation of Reflux Esophagitis-Like Symptoms in A Natural Village in A High-Incidence Area of Esophageal Cancer |
| title_short | Summary of 16-Year Observation of Reflux Esophagitis-Like Symptoms in A Natural Village in A High-Incidence Area of Esophageal Cancer |
| title_sort | summary of 16 year observation of reflux esophagitis like symptoms in a natural village in a high incidence area of esophageal cancer |
| topic | esophageal cancer high-incidence area reflux esophagitis epidemiological survey |
| url | http://www.zlfzyj.com/cn/article/doi/10.3971/j.issn.1000-8578.2025.24.1290 |
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