Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications
Mitophagy, a selective form of autophagy, plays a crucial role in maintaining optimal mitochondrial populations, normal function, and intracellular homeostasis by monitoring and removing damaged or excess mitochondria. Furthermore, mitophagy promotes mitochondrial degradation via the lysosomal pathw...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-10-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/14/10/1270 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850205731681206272 |
|---|---|
| author | Jiani Lin Xinyao Chen Yuyang Du Jiapeng Li Tingting Guo Sai Luo |
| author_facet | Jiani Lin Xinyao Chen Yuyang Du Jiapeng Li Tingting Guo Sai Luo |
| author_sort | Jiani Lin |
| collection | DOAJ |
| description | Mitophagy, a selective form of autophagy, plays a crucial role in maintaining optimal mitochondrial populations, normal function, and intracellular homeostasis by monitoring and removing damaged or excess mitochondria. Furthermore, mitophagy promotes mitochondrial degradation via the lysosomal pathway, and not only eliminates damaged mitochondria but also regulates programmed cell death-associated genes, thus preventing cell death. The interaction between mitophagy and various forms of cell death has recently gained increasing attention in relation to the pathogenesis of clinical diseases, such as cancers and osteoarthritis, neurodegenerative, cardiovascular, and renal diseases. However, despite the abundant literature on this subject, there is a lack of understanding regarding the interaction between mitophagy and cell death. In this review, we discuss the main pathways of mitophagy, those related to cell death mechanisms (including apoptosis, ferroptosis, and pyroptosis), and the relationship between mitophagy and cell death uncovered in recent years. Our study offers potential directions for therapeutic intervention and disease diagnosis, and contributes to understanding the molecular mechanism of mitophagy. |
| format | Article |
| id | doaj-art-487a542fdaef4c748b4b75dd3647fb80 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-487a542fdaef4c748b4b75dd3647fb802025-08-20T02:11:01ZengMDPI AGBiomolecules2218-273X2024-10-011410127010.3390/biom14101270Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease ImplicationsJiani Lin0Xinyao Chen1Yuyang Du2Jiapeng Li3Tingting Guo4Sai Luo5The 1st Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150000, ChinaThe 1st Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150000, ChinaThe 1st Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150000, ChinaThe 1st Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150000, ChinaThe 1st Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150000, ChinaThe 1st Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150000, ChinaMitophagy, a selective form of autophagy, plays a crucial role in maintaining optimal mitochondrial populations, normal function, and intracellular homeostasis by monitoring and removing damaged or excess mitochondria. Furthermore, mitophagy promotes mitochondrial degradation via the lysosomal pathway, and not only eliminates damaged mitochondria but also regulates programmed cell death-associated genes, thus preventing cell death. The interaction between mitophagy and various forms of cell death has recently gained increasing attention in relation to the pathogenesis of clinical diseases, such as cancers and osteoarthritis, neurodegenerative, cardiovascular, and renal diseases. However, despite the abundant literature on this subject, there is a lack of understanding regarding the interaction between mitophagy and cell death. In this review, we discuss the main pathways of mitophagy, those related to cell death mechanisms (including apoptosis, ferroptosis, and pyroptosis), and the relationship between mitophagy and cell death uncovered in recent years. Our study offers potential directions for therapeutic intervention and disease diagnosis, and contributes to understanding the molecular mechanism of mitophagy.https://www.mdpi.com/2218-273X/14/10/1270mitophagymitochondriaintracellular homeostasiscell death |
| spellingShingle | Jiani Lin Xinyao Chen Yuyang Du Jiapeng Li Tingting Guo Sai Luo Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications Biomolecules mitophagy mitochondria intracellular homeostasis cell death |
| title | Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications |
| title_full | Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications |
| title_fullStr | Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications |
| title_full_unstemmed | Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications |
| title_short | Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications |
| title_sort | mitophagy in cell death regulation insights into mechanisms and disease implications |
| topic | mitophagy mitochondria intracellular homeostasis cell death |
| url | https://www.mdpi.com/2218-273X/14/10/1270 |
| work_keys_str_mv | AT jianilin mitophagyincelldeathregulationinsightsintomechanismsanddiseaseimplications AT xinyaochen mitophagyincelldeathregulationinsightsintomechanismsanddiseaseimplications AT yuyangdu mitophagyincelldeathregulationinsightsintomechanismsanddiseaseimplications AT jiapengli mitophagyincelldeathregulationinsightsintomechanismsanddiseaseimplications AT tingtingguo mitophagyincelldeathregulationinsightsintomechanismsanddiseaseimplications AT sailuo mitophagyincelldeathregulationinsightsintomechanismsanddiseaseimplications |