Immune conversations at the border: meningeal immunity in health and disease
The brain and spinal cord, collectively known as the central nervous system, are encapsulated by an overlapping series of membranes known as the meninges. Once considered primarily a physical barrier for central nervous system protection, the bordering meninges are now recognized as highly immunolog...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531068/full |
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| author | Preya U. Patel Preya U. Patel Aryan Regmi Aryan Regmi Angelina I. Dass Angelina I. Dass Olga L. Rojas Olga L. Rojas |
| author_facet | Preya U. Patel Preya U. Patel Aryan Regmi Aryan Regmi Angelina I. Dass Angelina I. Dass Olga L. Rojas Olga L. Rojas |
| author_sort | Preya U. Patel |
| collection | DOAJ |
| description | The brain and spinal cord, collectively known as the central nervous system, are encapsulated by an overlapping series of membranes known as the meninges. Once considered primarily a physical barrier for central nervous system protection, the bordering meninges are now recognized as highly immunologically active. The meninges host diverse resident immune cells and serve as a critical interface with peripheral immunity, playing multifaceted roles in maintaining central nervous system homeostasis, responding to pathogenic threats, and neurological disorders. This review summarizes recent advancements in our understanding of meningeal immunity including its structural composition, physiological functions, and role in health and disease. |
| format | Article |
| id | doaj-art-487197eb69a645168b58de3a6f627d3f |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-487197eb69a645168b58de3a6f627d3f2025-01-29T05:21:18ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011610.3389/fimmu.2025.15310681531068Immune conversations at the border: meningeal immunity in health and diseasePreya U. Patel0Preya U. Patel1Aryan Regmi2Aryan Regmi3Angelina I. Dass4Angelina I. Dass5Olga L. Rojas6Olga L. Rojas7Department of Immunology, University of Toronto, Toronto, ON, CanadaKrembil Research Institute, University Health Network, Toronto, ON, CanadaDepartment of Immunology, University of Toronto, Toronto, ON, CanadaKrembil Research Institute, University Health Network, Toronto, ON, CanadaDepartment of Immunology, University of Toronto, Toronto, ON, CanadaKrembil Research Institute, University Health Network, Toronto, ON, CanadaDepartment of Immunology, University of Toronto, Toronto, ON, CanadaKrembil Research Institute, University Health Network, Toronto, ON, CanadaThe brain and spinal cord, collectively known as the central nervous system, are encapsulated by an overlapping series of membranes known as the meninges. Once considered primarily a physical barrier for central nervous system protection, the bordering meninges are now recognized as highly immunologically active. The meninges host diverse resident immune cells and serve as a critical interface with peripheral immunity, playing multifaceted roles in maintaining central nervous system homeostasis, responding to pathogenic threats, and neurological disorders. This review summarizes recent advancements in our understanding of meningeal immunity including its structural composition, physiological functions, and role in health and disease.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531068/fullmeningeal anatomymeningeal immunitycentral nervous systemimmune cells - dura materCNS diseases |
| spellingShingle | Preya U. Patel Preya U. Patel Aryan Regmi Aryan Regmi Angelina I. Dass Angelina I. Dass Olga L. Rojas Olga L. Rojas Immune conversations at the border: meningeal immunity in health and disease Frontiers in Immunology meningeal anatomy meningeal immunity central nervous system immune cells - dura mater CNS diseases |
| title | Immune conversations at the border: meningeal immunity in health and disease |
| title_full | Immune conversations at the border: meningeal immunity in health and disease |
| title_fullStr | Immune conversations at the border: meningeal immunity in health and disease |
| title_full_unstemmed | Immune conversations at the border: meningeal immunity in health and disease |
| title_short | Immune conversations at the border: meningeal immunity in health and disease |
| title_sort | immune conversations at the border meningeal immunity in health and disease |
| topic | meningeal anatomy meningeal immunity central nervous system immune cells - dura mater CNS diseases |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531068/full |
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