Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets
To explore whether Dendrobium officinale, Polygonatum sibiricum, and Ziziphus jujuba can be used as active pharmaceutical ingredient (APIs), a functional snack that is easy to carry and eat was developed. In this study, the design of experiment (DOE) scheme was used to determine the optimal ratio of...
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The editorial department of Science and Technology of Food Industry
2025-02-01
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| Series: | Shipin gongye ke-ji |
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| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024010147 |
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| author | Wenyu ZHANG Xianshu FU Xue BAI Shiwen WU Jiabin LI Xiaoping YU Mingzhou ZHANG Zihong YE |
| author_facet | Wenyu ZHANG Xianshu FU Xue BAI Shiwen WU Jiabin LI Xiaoping YU Mingzhou ZHANG Zihong YE |
| author_sort | Wenyu ZHANG |
| collection | DOAJ |
| description | To explore whether Dendrobium officinale, Polygonatum sibiricum, and Ziziphus jujuba can be used as active pharmaceutical ingredient (APIs), a functional snack that is easy to carry and eat was developed. In this study, the design of experiment (DOE) scheme was used to determine the optimal ratio of D. officinale, P. sibiricum, and Z. jujuba based on the measured mass fractions of polysaccharides, flavonoids, and polyphenols in the drug. A single-factor experiment was used to study the effects of excipients on the appearance, taste, hardness, and weight difference of chewable tablets, and the optimal formula was selected by combining the response surface optimization and multi-index weight methods. Results showed that the optimal compound ratio of the main ingredients of D. officinale chewable tablets (mass fraction) was D. officinale:P. sibiricum:Z. jujuba=35%:10%:5%, and the corresponding total mass fractions of polysaccharides, flavonoids, and polyphenols were 159.64±0.14, 79.44±0.35, and 78.10±0.28 mg/g, respectively. The mass fraction ratios of erythritol, mannitol, and whey protein in the excipient fractions were 13%, 13%, and 6%, respectively. The differences in appearance, taste, hardness, and weight of D. officinale chewable tablets under the optimal formula were 7.80±0.63 points, 7.80±0.42 points, 23.72±0.15 N, and 2.57%±0.13%, respectively. The comprehensive score was 21.87±0.83 points. Results of physical property evaluation and the dissolution test of D. officinale chewable tablets showed that the water content, adhesion, elasticity, and chewiness were 2.23%±0.92%, 12.75±0.54 mJ, 7.08±0.58 mm, and 0.41±0.67 mJ, respectively, and the cumulative dissolution reached 79.80%±0.75% at 60 min. Chewable tablets made from D. officinale, P. sibiricum, and Z. jujuba have a high active ingredient content, good sensory evaluation, and easy dissolution. |
| format | Article |
| id | doaj-art-486c1357918d466caeecd81cf40f1948 |
| institution | Kabale University |
| issn | 1002-0306 |
| language | zho |
| publishDate | 2025-02-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
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| series | Shipin gongye ke-ji |
| spelling | doaj-art-486c1357918d466caeecd81cf40f19482025-02-08T08:06:20ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062025-02-0146415516610.13386/j.issn1002-0306.20240101472024010147-4Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable TabletsWenyu ZHANG0Xianshu FU1Xue BAI2Shiwen WU3Jiabin LI4Xiaoping YU5Mingzhou ZHANG6Zihong YE7College of Life Sciences, China Jiliang University, Key Laboratory of Biometrics, Inspection and Quarantine of Zhejiang Province, Hangzhou 310018, ChinaCollege of Life Sciences, China Jiliang University, Key Laboratory of Biometrics, Inspection and Quarantine of Zhejiang Province, Hangzhou 310018, ChinaCollege of Life Sciences, China Jiliang University, Key Laboratory of Biometrics, Inspection and Quarantine of Zhejiang Province, Hangzhou 310018, ChinaCollege of Life Sciences, China Jiliang University, Key Laboratory of Biometrics, Inspection and Quarantine of Zhejiang Province, Hangzhou 310018, ChinaFood Company Limited of Hangzhou Baichen, Hangzhou 311251, ChinaCollege of Life Sciences, China Jiliang University, Key Laboratory of Biometrics, Inspection and Quarantine of Zhejiang Province, Hangzhou 310018, ChinaCollege of Life Sciences, China Jiliang University, Key Laboratory of Biometrics, Inspection and Quarantine of Zhejiang Province, Hangzhou 310018, ChinaCollege of Life Sciences, China Jiliang University, Key Laboratory of Biometrics, Inspection and Quarantine of Zhejiang Province, Hangzhou 310018, ChinaTo explore whether Dendrobium officinale, Polygonatum sibiricum, and Ziziphus jujuba can be used as active pharmaceutical ingredient (APIs), a functional snack that is easy to carry and eat was developed. In this study, the design of experiment (DOE) scheme was used to determine the optimal ratio of D. officinale, P. sibiricum, and Z. jujuba based on the measured mass fractions of polysaccharides, flavonoids, and polyphenols in the drug. A single-factor experiment was used to study the effects of excipients on the appearance, taste, hardness, and weight difference of chewable tablets, and the optimal formula was selected by combining the response surface optimization and multi-index weight methods. Results showed that the optimal compound ratio of the main ingredients of D. officinale chewable tablets (mass fraction) was D. officinale:P. sibiricum:Z. jujuba=35%:10%:5%, and the corresponding total mass fractions of polysaccharides, flavonoids, and polyphenols were 159.64±0.14, 79.44±0.35, and 78.10±0.28 mg/g, respectively. The mass fraction ratios of erythritol, mannitol, and whey protein in the excipient fractions were 13%, 13%, and 6%, respectively. The differences in appearance, taste, hardness, and weight of D. officinale chewable tablets under the optimal formula were 7.80±0.63 points, 7.80±0.42 points, 23.72±0.15 N, and 2.57%±0.13%, respectively. The comprehensive score was 21.87±0.83 points. Results of physical property evaluation and the dissolution test of D. officinale chewable tablets showed that the water content, adhesion, elasticity, and chewiness were 2.23%±0.92%, 12.75±0.54 mJ, 7.08±0.58 mm, and 0.41±0.67 mJ, respectively, and the cumulative dissolution reached 79.80%±0.75% at 60 min. Chewable tablets made from D. officinale, P. sibiricum, and Z. jujuba have a high active ingredient content, good sensory evaluation, and easy dissolution.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024010147dendrobium officinalechewable tabletsdesign of experimentresponse surface optimizationdissolution |
| spellingShingle | Wenyu ZHANG Xianshu FU Xue BAI Shiwen WU Jiabin LI Xiaoping YU Mingzhou ZHANG Zihong YE Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets Shipin gongye ke-ji dendrobium officinale chewable tablets design of experiment response surface optimization dissolution |
| title | Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets |
| title_full | Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets |
| title_fullStr | Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets |
| title_full_unstemmed | Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets |
| title_short | Formulation Optimization and Quality Analysis of Dendrobium officinale Chewable Tablets |
| title_sort | formulation optimization and quality analysis of dendrobium officinale chewable tablets |
| topic | dendrobium officinale chewable tablets design of experiment response surface optimization dissolution |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2024010147 |
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