Urgent percutaneous coronary intervention leads to a decrease in serum concentrations of soluble CD40 ligand
Background/Aim. Inflammation as a consequence of vascular injury after percutaneous coronary intervention (PCI) is a pathological substrate of restenosis and of its complications. The aim of the study was to examine perprocedural inflammatory response expressed by soluble CD40 ligand (sCD40L) and C-...
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| Format: | Article |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2010-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501009732R.pdf |
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| author | Ratković Nenad Romanović Radoslav Jovelić Aleksandra Gligić Branko Rafajlovski Sašo Vojvodić Danilo Obradović Slobodan |
| author_facet | Ratković Nenad Romanović Radoslav Jovelić Aleksandra Gligić Branko Rafajlovski Sašo Vojvodić Danilo Obradović Slobodan |
| author_sort | Ratković Nenad |
| collection | DOAJ |
| description | Background/Aim. Inflammation as a consequence of vascular injury after percutaneous coronary intervention (PCI) is a pathological substrate of restenosis and of its complications. The aim of the study was to examine perprocedural inflammatory response expressed by soluble CD40 ligand (sCD40L) and C-reactive protein (CRP) in patients treated with PCI and dual antiplatelet therapy. Methods. The experimental group included 52 patients (80.8% men, age 60 ± 9 years) with angina pectoris treated by PCI (22 urgent PCI) with stent implantation, and dual antiplatelet therapy (tienopiridins and aspirin), according to the current recommendations for the execution of the intervention. The control group consisted of 8 patients (70.5% men, age 59 ± 7 years) with angina pectoris, who had undergone coronarography taking aspirin 3 days prior to it. In all the patients 24 hours before and after the PCI concentrations of CRP and sCD40L in the blood were determined. Results. In the experimental group, the concentration of sCD40L was lower as compared to the control (p < 0.02). In 34 (65%) patients postprocedural decrease in sCD40L was recorded, in 18 (34.6%) of them increase, while in 50 (96%) patients there was a rise in CRP. The patients with postprocedural fall in sCD40L hod greater preprocedural concentration of sCD40L (p < 0.001), and less postprocedural concentration of sCD40L (p < 0.001), compared to the group with an increase in sCD40L after the PCI, while CRP levels tients treated with emergency PCI compared to elective patietns had a postprocedural decrease in sCD40L (p = 0.02). Increase in the level of CRP was higher in the group with emergency PCI in relation to elective PCI (p < 0.01). Conclusion. Emergency PCI procedures in the treatment of patients with unstable angina pectoris lead to a postprocedural fall in the serum concentration of sCD40L. Dual antiplate therapy with tienopiridins and aspirin inhibits the release of sCD40L. Regardless a clinical presentation of coronary disease PCI leads to an postprocedural increase in concentrations of CRP in the serum. |
| format | Article |
| id | doaj-art-486a538fd28242f8875e45db4986e2e8 |
| institution | OA Journals |
| issn | 0042-8450 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-486a538fd28242f8875e45db4986e2e82025-08-20T02:38:01ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502010-01-0167973274010.2298/VSP1009732RUrgent percutaneous coronary intervention leads to a decrease in serum concentrations of soluble CD40 ligandRatković NenadRomanović RadoslavJovelić AleksandraGligić BrankoRafajlovski SašoVojvodić DaniloObradović SlobodanBackground/Aim. Inflammation as a consequence of vascular injury after percutaneous coronary intervention (PCI) is a pathological substrate of restenosis and of its complications. The aim of the study was to examine perprocedural inflammatory response expressed by soluble CD40 ligand (sCD40L) and C-reactive protein (CRP) in patients treated with PCI and dual antiplatelet therapy. Methods. The experimental group included 52 patients (80.8% men, age 60 ± 9 years) with angina pectoris treated by PCI (22 urgent PCI) with stent implantation, and dual antiplatelet therapy (tienopiridins and aspirin), according to the current recommendations for the execution of the intervention. The control group consisted of 8 patients (70.5% men, age 59 ± 7 years) with angina pectoris, who had undergone coronarography taking aspirin 3 days prior to it. In all the patients 24 hours before and after the PCI concentrations of CRP and sCD40L in the blood were determined. Results. In the experimental group, the concentration of sCD40L was lower as compared to the control (p < 0.02). In 34 (65%) patients postprocedural decrease in sCD40L was recorded, in 18 (34.6%) of them increase, while in 50 (96%) patients there was a rise in CRP. The patients with postprocedural fall in sCD40L hod greater preprocedural concentration of sCD40L (p < 0.001), and less postprocedural concentration of sCD40L (p < 0.001), compared to the group with an increase in sCD40L after the PCI, while CRP levels tients treated with emergency PCI compared to elective patietns had a postprocedural decrease in sCD40L (p = 0.02). Increase in the level of CRP was higher in the group with emergency PCI in relation to elective PCI (p < 0.01). Conclusion. Emergency PCI procedures in the treatment of patients with unstable angina pectoris lead to a postprocedural fall in the serum concentration of sCD40L. Dual antiplate therapy with tienopiridins and aspirin inhibits the release of sCD40L. Regardless a clinical presentation of coronary disease PCI leads to an postprocedural increase in concentrations of CRP in the serum.http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501009732R.pdfarteriosclerosisinflammation mediatorsangioplasty, baloonplatelet aggregation inhibitors |
| spellingShingle | Ratković Nenad Romanović Radoslav Jovelić Aleksandra Gligić Branko Rafajlovski Sašo Vojvodić Danilo Obradović Slobodan Urgent percutaneous coronary intervention leads to a decrease in serum concentrations of soluble CD40 ligand Vojnosanitetski Pregled arteriosclerosis inflammation mediators angioplasty, baloon platelet aggregation inhibitors |
| title | Urgent percutaneous coronary intervention leads to a decrease in serum concentrations of soluble CD40 ligand |
| title_full | Urgent percutaneous coronary intervention leads to a decrease in serum concentrations of soluble CD40 ligand |
| title_fullStr | Urgent percutaneous coronary intervention leads to a decrease in serum concentrations of soluble CD40 ligand |
| title_full_unstemmed | Urgent percutaneous coronary intervention leads to a decrease in serum concentrations of soluble CD40 ligand |
| title_short | Urgent percutaneous coronary intervention leads to a decrease in serum concentrations of soluble CD40 ligand |
| title_sort | urgent percutaneous coronary intervention leads to a decrease in serum concentrations of soluble cd40 ligand |
| topic | arteriosclerosis inflammation mediators angioplasty, baloon platelet aggregation inhibitors |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501009732R.pdf |
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