Pre-Administration of <i>Saccharomyces boulardii</i>-Derived Postbiotics Effectively Prevents Dextran Sulfate Sodium-Induced Colitis in Mice
Ulcerative colitis (UC) is effectively alleviated by <i>Saccharomyces boulardii</i> (<i>S. boulardii</i>), an important probiotic. Postbiotics, defined as beneficial non-viable microorganisms and/or their components, can potentially improve gut health. In this study, we utili...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
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| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/14/7/1109 |
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| Summary: | Ulcerative colitis (UC) is effectively alleviated by <i>Saccharomyces boulardii</i> (<i>S. boulardii</i>), an important probiotic. Postbiotics, defined as beneficial non-viable microorganisms and/or their components, can potentially improve gut health. In this study, we utilized <i>S. boulardii</i> to prepare postbiotics via freeze-drying and spray-drying methods, characterized the resulting postbiotics, and investigated their efficacy and underlying mechanisms in preventing UC. In a mouse model of UC induced by dextran sulfate sodium (DSS), we found that prevention with two forms of <i>S. boulardii</i> postbiotics alleviated colitis symptoms triggered by DSS, mitigated colon tissue damage, maintained the distribution of intestinal occludin and ZO-1 proteins, and suppressed the secretion and expression of TNF-α, IL-1β, and IL-6 in serum and colon tissues. Additionally, <i>S. boulardii</i> postbiotics mitigated dysbiosis by modulating gut microbiota composition, including the balance between Bacteroidota and Firmicutes (F/B), as well as the levels of <i>Akkermansia</i>, <i>Muribaculaceae</i>, <i>Dubosiella</i>, and <i>Turicibacter</i>. In conclusion, as a novel biotherapeutic agent, <i>S. boulardii</i> postbiotics effectively prevent DSS-induced UC in mice. Compared to live <i>S. boulardii</i>, postbiotics may hold greater potential for UC prevention. |
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| ISSN: | 2304-8158 |