A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in an HIV Patient Treated with CHOP
Anaplastic large cell lymphoma (ALCL) is the second most common malignancy of T-cell phenotype. This case report describes an unusual rapidly progressing cutaneous anaplastic large T-cell lymphoma in an HIV patient. Our patient is a twenty-year-old African American male with perinatally acquired HIV...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/805893 |
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| author | Jorge Hurtado-Cordovi Louay Hanna Vladimir Gotlieb Alan S. Multz Anastasia Pigal |
| author_facet | Jorge Hurtado-Cordovi Louay Hanna Vladimir Gotlieb Alan S. Multz Anastasia Pigal |
| author_sort | Jorge Hurtado-Cordovi |
| collection | DOAJ |
| description | Anaplastic large cell lymphoma (ALCL) is the second most common malignancy of T-cell phenotype. This case report describes an unusual rapidly progressing cutaneous anaplastic large T-cell lymphoma in an HIV patient. Our patient is a twenty-year-old African American male with perinatally acquired HIV who presented with a 2×2 centimeter necrotic lesion in the right 1st toe; however, 2-3 weeks later multiple smaller lesions appeared on the anterior aspect of the right foot, ankle, and thigh. Biopsy showed cells strongly positive for CD3 and CD30 and negative for CD56 and the ALK gene product. CT of the chest, abdomen, and pelvis was negative for extracutaneous involvement favoring cutaneous ALCL. Patient was treated with 6 cycles of CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone) chemotherapy and went into complete remission. Due to the aggressive course that this malignancy follows in HIV patients we suggest prompt treatment with systemic therapy. |
| format | Article |
| id | doaj-art-4861346236d64225a5a4802373c5716f |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-4861346236d64225a5a4802373c5716f2025-02-03T01:09:41ZengWileyCase Reports in Oncological Medicine2090-67062090-67142011-01-01201110.1155/2011/805893805893A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in an HIV Patient Treated with CHOPJorge Hurtado-Cordovi0Louay Hanna1Vladimir Gotlieb2Alan S. Multz3Anastasia Pigal4Division of Hematology and Oncology, Department of Medicine, Nassau University Medical Center, North Shore LIJ Health Care System, 2201 Hempstead Turnpike, East Meadow, NY 11554, USADivision of Hematology and Oncology, Department of Medicine, Nassau University Medical Center, North Shore LIJ Health Care System, 2201 Hempstead Turnpike, East Meadow, NY 11554, USADivision of Hematology and Oncology, Department of Medicine, Nassau University Medical Center, North Shore LIJ Health Care System, 2201 Hempstead Turnpike, East Meadow, NY 11554, USADivision of Hematology and Oncology, Department of Medicine, Nassau University Medical Center, North Shore LIJ Health Care System, 2201 Hempstead Turnpike, East Meadow, NY 11554, USADepartment of Pathology, Nassau University Medical Center, North Shore LIJ Health Care System, 2201 Hempstead Turnpike, East Meadow, NY 11554, USAAnaplastic large cell lymphoma (ALCL) is the second most common malignancy of T-cell phenotype. This case report describes an unusual rapidly progressing cutaneous anaplastic large T-cell lymphoma in an HIV patient. Our patient is a twenty-year-old African American male with perinatally acquired HIV who presented with a 2×2 centimeter necrotic lesion in the right 1st toe; however, 2-3 weeks later multiple smaller lesions appeared on the anterior aspect of the right foot, ankle, and thigh. Biopsy showed cells strongly positive for CD3 and CD30 and negative for CD56 and the ALK gene product. CT of the chest, abdomen, and pelvis was negative for extracutaneous involvement favoring cutaneous ALCL. Patient was treated with 6 cycles of CHOP (cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone) chemotherapy and went into complete remission. Due to the aggressive course that this malignancy follows in HIV patients we suggest prompt treatment with systemic therapy.http://dx.doi.org/10.1155/2011/805893 |
| spellingShingle | Jorge Hurtado-Cordovi Louay Hanna Vladimir Gotlieb Alan S. Multz Anastasia Pigal A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in an HIV Patient Treated with CHOP Case Reports in Oncological Medicine |
| title | A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in an HIV Patient Treated with CHOP |
| title_full | A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in an HIV Patient Treated with CHOP |
| title_fullStr | A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in an HIV Patient Treated with CHOP |
| title_full_unstemmed | A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in an HIV Patient Treated with CHOP |
| title_short | A Case of an Unusually Aggressive Cutaneous Anaplastic Large T-Cell Lymphoma in an HIV Patient Treated with CHOP |
| title_sort | case of an unusually aggressive cutaneous anaplastic large t cell lymphoma in an hiv patient treated with chop |
| url | http://dx.doi.org/10.1155/2011/805893 |
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