Extracorporeal shock wave therapy for peripheral arterial disease-related intermittent claudication: a systematic review and meta-analysis
Background Intermittent claudication (IC) is a common manifestation of peripheral arterial disease. This study evaluates the efficacy of extracorporeal shock wave therapy (ESWT), a non-invasive treatment, for patients with IC.Methods A systematic review and meta-analysis of four major databases (Pub...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2543979 |
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| author | Peiyuan Tang Ting Wen Jingyue Su Shanshan Gao Shengwu Yang Chunwu Zhang Wenfeng Xiao Yusheng Li Zhenhan Deng |
| author_facet | Peiyuan Tang Ting Wen Jingyue Su Shanshan Gao Shengwu Yang Chunwu Zhang Wenfeng Xiao Yusheng Li Zhenhan Deng |
| author_sort | Peiyuan Tang |
| collection | DOAJ |
| description | Background Intermittent claudication (IC) is a common manifestation of peripheral arterial disease. This study evaluates the efficacy of extracorporeal shock wave therapy (ESWT), a non-invasive treatment, for patients with IC.Methods A systematic review and meta-analysis of four major databases (PubMed, Embase, Cochrane Library, Web of Science) was conducted through March 2025. Eight studies met inclusion criteria for the analysis, which was performed using Review Manager 5.4 with evidence strength assessed by the GRADE system.Results The analysis included eight studies with a total of 332 patients (mean age >50 years, 67.5% male). Compared to placebo, ESWT demonstrated significant improvements in functional outcomes. It led to substantial increases in both Pain-Free Walking Distance (MD=26.53, p < 0.01) and Maximum Walking Distance (MD=37.21, p < 0.01). Quality of life was also enhanced, reflected by higher scores on the EQ-5D-3L survey (MD=0.08, p < 0.01) and improvements across SF-36 domains including Physical Function, General Health, Vitality, and Social Functioning. However, ESWT did not produce a significant change in the Ankle-Brachial Index (ABI) (MD=−0.01, p = 0.05).Conclusion ESWT is associated with improved walking distance and quality of life in patients with IC. These findings require cautious interpretation due to the limited number of studies and small sample sizes.Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-485da11c983949cb9c7fe2f6a26d2b16 |
| institution | Kabale University |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-485da11c983949cb9c7fe2f6a26d2b162025-08-20T03:45:11ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2543979Extracorporeal shock wave therapy for peripheral arterial disease-related intermittent claudication: a systematic review and meta-analysisPeiyuan Tang0Ting Wen1Jingyue Su2Shanshan Gao3Shengwu Yang4Chunwu Zhang5Wenfeng Xiao6Yusheng Li7Zhenhan Deng8Deparment of Orthopedics, Xiangya Hospital, Central South University, Hunan, ChinaDeparment of Orthopedics, Xiangya Hospital, Central South University, Hunan, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, University of Colorado Denver, Aurora, CO, USADepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDeparment of Orthopedics, Xiangya Hospital, Central South University, Hunan, ChinaDeparment of Orthopedics, Xiangya Hospital, Central South University, Hunan, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaBackground Intermittent claudication (IC) is a common manifestation of peripheral arterial disease. This study evaluates the efficacy of extracorporeal shock wave therapy (ESWT), a non-invasive treatment, for patients with IC.Methods A systematic review and meta-analysis of four major databases (PubMed, Embase, Cochrane Library, Web of Science) was conducted through March 2025. Eight studies met inclusion criteria for the analysis, which was performed using Review Manager 5.4 with evidence strength assessed by the GRADE system.Results The analysis included eight studies with a total of 332 patients (mean age >50 years, 67.5% male). Compared to placebo, ESWT demonstrated significant improvements in functional outcomes. It led to substantial increases in both Pain-Free Walking Distance (MD=26.53, p < 0.01) and Maximum Walking Distance (MD=37.21, p < 0.01). Quality of life was also enhanced, reflected by higher scores on the EQ-5D-3L survey (MD=0.08, p < 0.01) and improvements across SF-36 domains including Physical Function, General Health, Vitality, and Social Functioning. However, ESWT did not produce a significant change in the Ankle-Brachial Index (ABI) (MD=−0.01, p = 0.05).Conclusion ESWT is associated with improved walking distance and quality of life in patients with IC. These findings require cautious interpretation due to the limited number of studies and small sample sizes.Clinical trial number Not applicable.https://www.tandfonline.com/doi/10.1080/07853890.2025.2543979Extracorporeal shock wave therapyintermittent claudicationmeta-analysissystematic review |
| spellingShingle | Peiyuan Tang Ting Wen Jingyue Su Shanshan Gao Shengwu Yang Chunwu Zhang Wenfeng Xiao Yusheng Li Zhenhan Deng Extracorporeal shock wave therapy for peripheral arterial disease-related intermittent claudication: a systematic review and meta-analysis Annals of Medicine Extracorporeal shock wave therapy intermittent claudication meta-analysis systematic review |
| title | Extracorporeal shock wave therapy for peripheral arterial disease-related intermittent claudication: a systematic review and meta-analysis |
| title_full | Extracorporeal shock wave therapy for peripheral arterial disease-related intermittent claudication: a systematic review and meta-analysis |
| title_fullStr | Extracorporeal shock wave therapy for peripheral arterial disease-related intermittent claudication: a systematic review and meta-analysis |
| title_full_unstemmed | Extracorporeal shock wave therapy for peripheral arterial disease-related intermittent claudication: a systematic review and meta-analysis |
| title_short | Extracorporeal shock wave therapy for peripheral arterial disease-related intermittent claudication: a systematic review and meta-analysis |
| title_sort | extracorporeal shock wave therapy for peripheral arterial disease related intermittent claudication a systematic review and meta analysis |
| topic | Extracorporeal shock wave therapy intermittent claudication meta-analysis systematic review |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2543979 |
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