Changes in brain functional connectivity between on and off states and their relationship with cognitive impairment in Parkinson’s disease
Abstract Parkinson’s disease (PD) is characterized by motor and non-motor symptoms. Cognitive decline is crucial in disease progression and affect quality of life; however, their underlying mechanisms in PD remain unclear. We explored the relationship between cognitive impairment and functional conn...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-78642-6 |
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| author | Kaoru Kinugawa Tomoo Mano Kazuma Sugie |
| author_facet | Kaoru Kinugawa Tomoo Mano Kazuma Sugie |
| author_sort | Kaoru Kinugawa |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD) is characterized by motor and non-motor symptoms. Cognitive decline is crucial in disease progression and affect quality of life; however, their underlying mechanisms in PD remain unclear. We explored the relationship between cognitive impairment and functional connectivity (FC) using resting-state functional magnetic resonance imaging in 26 patients with sporadic PD, focusing on the changes in FC between on and off states. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) score. The correlation between MMSE scores and changes in FC values during on and off states was assessed using Pearson’s correlation coefficient. The correlation between changes in FC during the on and off periods and cognitive function differed for each cognitive function item. MMSE memory scores were positively correlated with FC between the brainstem and the left cerebral hemisphere. MMSE attention scores were positively correlated with FC between the bilateral thalamus and frontal lobes and negatively correlated with FC between the left cerebral hemispheres. These findings may facilitate our understanding of the neural correlates underlying cognitive impairment in PD and help develop treatment strategies to preserve cognitive function. |
| format | Article |
| id | doaj-art-485bc77e04a448a3ac89e3052ed782b3 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-485bc77e04a448a3ac89e3052ed782b32025-08-20T02:49:58ZengNature PortfolioScientific Reports2045-23222024-11-0114111010.1038/s41598-024-78642-6Changes in brain functional connectivity between on and off states and their relationship with cognitive impairment in Parkinson’s diseaseKaoru Kinugawa0Tomoo Mano1Kazuma Sugie2Department of Neurology, Nara Medical UniversityDepartment of Neurology, Nara Medical UniversityDepartment of Neurology, Nara Medical UniversityAbstract Parkinson’s disease (PD) is characterized by motor and non-motor symptoms. Cognitive decline is crucial in disease progression and affect quality of life; however, their underlying mechanisms in PD remain unclear. We explored the relationship between cognitive impairment and functional connectivity (FC) using resting-state functional magnetic resonance imaging in 26 patients with sporadic PD, focusing on the changes in FC between on and off states. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) score. The correlation between MMSE scores and changes in FC values during on and off states was assessed using Pearson’s correlation coefficient. The correlation between changes in FC during the on and off periods and cognitive function differed for each cognitive function item. MMSE memory scores were positively correlated with FC between the brainstem and the left cerebral hemisphere. MMSE attention scores were positively correlated with FC between the bilateral thalamus and frontal lobes and negatively correlated with FC between the left cerebral hemispheres. These findings may facilitate our understanding of the neural correlates underlying cognitive impairment in PD and help develop treatment strategies to preserve cognitive function.https://doi.org/10.1038/s41598-024-78642-6Parkinson’s disease (PD)Functional connectivityResting-state functional MRIOn and off states in PDMini-mental state examinationMotor and non-motor symptoms |
| spellingShingle | Kaoru Kinugawa Tomoo Mano Kazuma Sugie Changes in brain functional connectivity between on and off states and their relationship with cognitive impairment in Parkinson’s disease Scientific Reports Parkinson’s disease (PD) Functional connectivity Resting-state functional MRI On and off states in PD Mini-mental state examination Motor and non-motor symptoms |
| title | Changes in brain functional connectivity between on and off states and their relationship with cognitive impairment in Parkinson’s disease |
| title_full | Changes in brain functional connectivity between on and off states and their relationship with cognitive impairment in Parkinson’s disease |
| title_fullStr | Changes in brain functional connectivity between on and off states and their relationship with cognitive impairment in Parkinson’s disease |
| title_full_unstemmed | Changes in brain functional connectivity between on and off states and their relationship with cognitive impairment in Parkinson’s disease |
| title_short | Changes in brain functional connectivity between on and off states and their relationship with cognitive impairment in Parkinson’s disease |
| title_sort | changes in brain functional connectivity between on and off states and their relationship with cognitive impairment in parkinson s disease |
| topic | Parkinson’s disease (PD) Functional connectivity Resting-state functional MRI On and off states in PD Mini-mental state examination Motor and non-motor symptoms |
| url | https://doi.org/10.1038/s41598-024-78642-6 |
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