Ocular manifestations and treatment safety in hepatitis C patients undergoing direct-acting antiviral therapy: a prospective cohort study
ABSTRACT Objective: To report the frequency of ocular manifestations in patients undergoing direct-acting antiviral therapy and assess treatment safety based on outcomes; to identify demographic variables associated with hepatitis C virus infection; evaluate treatment effectiveness through sustaine...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Oftalmologia
2025-02-01
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| Series: | Revista Brasileira de Oftalmologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100203&lng=en&tlng=en |
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| author | Guilherme Thomé de Carvalho Carlos Eduardo Brandão Mello Kelma Macedo Pohlmann Simões Mário Martins dos Santos Motta Max Kopti Fakoury Bruno Vasconcelos Coimbra Laura Gomes Nunes Melo Flávio Mac Cord Medina |
| author_facet | Guilherme Thomé de Carvalho Carlos Eduardo Brandão Mello Kelma Macedo Pohlmann Simões Mário Martins dos Santos Motta Max Kopti Fakoury Bruno Vasconcelos Coimbra Laura Gomes Nunes Melo Flávio Mac Cord Medina |
| author_sort | Guilherme Thomé de Carvalho |
| collection | DOAJ |
| description | ABSTRACT Objective: To report the frequency of ocular manifestations in patients undergoing direct-acting antiviral therapy and assess treatment safety based on outcomes; to identify demographic variables associated with hepatitis C virus infection; evaluate treatment effectiveness through sustained virological response. Methods: A prospective cohort study was conducted involving chronic hepatitis C patients undergoing direct-acting antiviral therapy. Ophthalmological evaluations were conducted before treatment initiation and upon completion. Patients were advised to return in case of any visual symptoms. Results: The study comprised 30 patients, predominantly treated with sofosbuvir + velpatasvir. All patients achieved sustained virological response, and a notable improvement in fibrosis degree post-treatment was observed. No ocular complications attributable to direct-acting antiviral therapy were reported during the study. Conclusion: This study underscores the safety profile of direct-acting antiviral therapy concerning ocular manifestations. Demographic trends align with existing literature, and all patients achieved sustained virological response alongside improved liver fibrosis. These findings support the efficacy and safety of direct-acting antiviral therapy for hepatitis C patients. |
| format | Article |
| id | doaj-art-485bb12e00624f239636deb7e217904d |
| institution | Kabale University |
| issn | 1982-8551 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Sociedade Brasileira de Oftalmologia |
| record_format | Article |
| series | Revista Brasileira de Oftalmologia |
| spelling | doaj-art-485bb12e00624f239636deb7e217904d2025-02-11T07:43:54ZengSociedade Brasileira de OftalmologiaRevista Brasileira de Oftalmologia1982-85512025-02-018410.37039/1982.8551.2025.0006Ocular manifestations and treatment safety in hepatitis C patients undergoing direct-acting antiviral therapy: a prospective cohort studyGuilherme Thomé de Carvalhohttps://orcid.org/0000-0003-4801-7007Carlos Eduardo Brandão Mellohttps://orcid.org/0000-0001-8965-6556Kelma Macedo Pohlmann Simõeshttps://orcid.org/0000-0003-3230-5530Mário Martins dos Santos Mottahttps://orcid.org/0000-0002-1892-6480Max Kopti Fakouryhttps://orcid.org/0000-0002-7003-9942Bruno Vasconcelos Coimbrahttps://orcid.org/0000-0002-2938-7072Laura Gomes Nunes Melohttps://orcid.org/0000-0001-5676-2213Flávio Mac Cord Medinahttps://orcid.org/0000-0003-2656-2960ABSTRACT Objective: To report the frequency of ocular manifestations in patients undergoing direct-acting antiviral therapy and assess treatment safety based on outcomes; to identify demographic variables associated with hepatitis C virus infection; evaluate treatment effectiveness through sustained virological response. Methods: A prospective cohort study was conducted involving chronic hepatitis C patients undergoing direct-acting antiviral therapy. Ophthalmological evaluations were conducted before treatment initiation and upon completion. Patients were advised to return in case of any visual symptoms. Results: The study comprised 30 patients, predominantly treated with sofosbuvir + velpatasvir. All patients achieved sustained virological response, and a notable improvement in fibrosis degree post-treatment was observed. No ocular complications attributable to direct-acting antiviral therapy were reported during the study. Conclusion: This study underscores the safety profile of direct-acting antiviral therapy concerning ocular manifestations. Demographic trends align with existing literature, and all patients achieved sustained virological response alongside improved liver fibrosis. These findings support the efficacy and safety of direct-acting antiviral therapy for hepatitis C patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100203&lng=en&tlng=enManifestações ocularesHepatite CAntiviraisSofosbuvirVelpatasvirResultado do tratamento |
| spellingShingle | Guilherme Thomé de Carvalho Carlos Eduardo Brandão Mello Kelma Macedo Pohlmann Simões Mário Martins dos Santos Motta Max Kopti Fakoury Bruno Vasconcelos Coimbra Laura Gomes Nunes Melo Flávio Mac Cord Medina Ocular manifestations and treatment safety in hepatitis C patients undergoing direct-acting antiviral therapy: a prospective cohort study Revista Brasileira de Oftalmologia Manifestações oculares Hepatite C Antivirais Sofosbuvir Velpatasvir Resultado do tratamento |
| title | Ocular manifestations and treatment safety in hepatitis C patients undergoing direct-acting antiviral therapy: a prospective cohort study |
| title_full | Ocular manifestations and treatment safety in hepatitis C patients undergoing direct-acting antiviral therapy: a prospective cohort study |
| title_fullStr | Ocular manifestations and treatment safety in hepatitis C patients undergoing direct-acting antiviral therapy: a prospective cohort study |
| title_full_unstemmed | Ocular manifestations and treatment safety in hepatitis C patients undergoing direct-acting antiviral therapy: a prospective cohort study |
| title_short | Ocular manifestations and treatment safety in hepatitis C patients undergoing direct-acting antiviral therapy: a prospective cohort study |
| title_sort | ocular manifestations and treatment safety in hepatitis c patients undergoing direct acting antiviral therapy a prospective cohort study |
| topic | Manifestações oculares Hepatite C Antivirais Sofosbuvir Velpatasvir Resultado do tratamento |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-72802025000100203&lng=en&tlng=en |
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