The alterations of ocular surface metabolism and the related immunity inflammation in dry eye
Background: Dry eye disease (DED) stands as a prominent ocular condition of global prevalence, emerging as a growing concern within public health. However, the underlying mechanisms involved in its pathogenesis remain largely unknown. In recent years, with the development of metabolomics, numerous s...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Advances in Ophthalmology Practice and Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667376224000519 |
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| author | Xiaojie Wan Yu Zhang Kaiye Zhang Yujie Mou Xiuming Jin Xiaodan Huang |
| author_facet | Xiaojie Wan Yu Zhang Kaiye Zhang Yujie Mou Xiuming Jin Xiaodan Huang |
| author_sort | Xiaojie Wan |
| collection | DOAJ |
| description | Background: Dry eye disease (DED) stands as a prominent ocular condition of global prevalence, emerging as a growing concern within public health. However, the underlying mechanisms involved in its pathogenesis remain largely unknown. In recent years, with the development of metabolomics, numerous studies have reported alterations in ocular surface metabolism in DED and offered fresh perspectives on the development of DED. Main text: The metabolic changes of the ocular surface of DED patients are closely intertwined with the cellular metabolism process and immune inflammation changes. This article expounds upon the correlation between ocular surface metabolism and immune inflammation alterations in DED in terms of glycolysis, lipid metabolism, amino acid metabolism, cellular signaling pathways, and immune inflammation regulation. Conclusions: The alterations in ocular surface metabolism of patients with dry eye are closely associated with their inflammatory status. Our work contributes novel insights into the pathogenesis of dry eye diseases and offers innovative molecular targets for diagnosing, detecting, and managing DED patients. |
| format | Article |
| id | doaj-art-485a49ecdb1942ebb3ed95343719612a |
| institution | DOAJ |
| issn | 2667-3762 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Ophthalmology Practice and Research |
| spelling | doaj-art-485a49ecdb1942ebb3ed95343719612a2025-08-20T02:45:27ZengElsevierAdvances in Ophthalmology Practice and Research2667-37622025-02-015111210.1016/j.aopr.2024.08.003The alterations of ocular surface metabolism and the related immunity inflammation in dry eyeXiaojie Wan0Yu Zhang1Kaiye Zhang2Yujie Mou3Xiuming Jin4Xiaodan Huang5Eye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, ChinaEye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, ChinaEye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, ChinaEye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, ChinaEye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, ChinaEye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, China; Corresponding author. Eye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China.Background: Dry eye disease (DED) stands as a prominent ocular condition of global prevalence, emerging as a growing concern within public health. However, the underlying mechanisms involved in its pathogenesis remain largely unknown. In recent years, with the development of metabolomics, numerous studies have reported alterations in ocular surface metabolism in DED and offered fresh perspectives on the development of DED. Main text: The metabolic changes of the ocular surface of DED patients are closely intertwined with the cellular metabolism process and immune inflammation changes. This article expounds upon the correlation between ocular surface metabolism and immune inflammation alterations in DED in terms of glycolysis, lipid metabolism, amino acid metabolism, cellular signaling pathways, and immune inflammation regulation. Conclusions: The alterations in ocular surface metabolism of patients with dry eye are closely associated with their inflammatory status. Our work contributes novel insights into the pathogenesis of dry eye diseases and offers innovative molecular targets for diagnosing, detecting, and managing DED patients.http://www.sciencedirect.com/science/article/pii/S2667376224000519Dry eye diseaseMetabolismCell signaling pathwaysImmune inflammation |
| spellingShingle | Xiaojie Wan Yu Zhang Kaiye Zhang Yujie Mou Xiuming Jin Xiaodan Huang The alterations of ocular surface metabolism and the related immunity inflammation in dry eye Advances in Ophthalmology Practice and Research Dry eye disease Metabolism Cell signaling pathways Immune inflammation |
| title | The alterations of ocular surface metabolism and the related immunity inflammation in dry eye |
| title_full | The alterations of ocular surface metabolism and the related immunity inflammation in dry eye |
| title_fullStr | The alterations of ocular surface metabolism and the related immunity inflammation in dry eye |
| title_full_unstemmed | The alterations of ocular surface metabolism and the related immunity inflammation in dry eye |
| title_short | The alterations of ocular surface metabolism and the related immunity inflammation in dry eye |
| title_sort | alterations of ocular surface metabolism and the related immunity inflammation in dry eye |
| topic | Dry eye disease Metabolism Cell signaling pathways Immune inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2667376224000519 |
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