Ultrasound combined with microbubble enhanced renoprotective effects of NLRP3 inflammasome inhibitor MCC950 in CKD model

Ultrasound combined with microbubble enhanced renoprotective effects of NLRP3 inflammasome inhibitor MCC950 in CKD model

ObjectiveThis study evaluated the effectiveness of the NLRP3 inflammasome inhibitor MCC950 combined with ultrasound (US) and microbubbles (MBs) on kidney function and fibrosis in a rat model of chronic kidney disease (CKD).MethodsAfter establishing the model, SD rats were divided into eight groups (...

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Bibliographic Details
Main Authors: Wen Wen, Bin Tu, Xiaomei Ren, Yangli Liu, Rufang Jiang, Xiaofeng Wu, Jian Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
ultrasound
microbubble
CKD
renal fibrosis
NLRP3
MCC950
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1616542/full
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