The neuroscience in breast cancer: Current insights and clinical opportunities
The involvement of nerves in the development of breast cancer has emerged as a significant factor. Interaction between the nervous system and breast cancer can influence tumor initiation, growth, invasion, metastasis, reverse resistance to drugs, promote inflammation in tumors, and impair the immune...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025006735 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832573072172908544 |
|---|---|
| author | Jia-feng Wang Meng-chuan Wang Lei-lei Jiang Neng-ming Lin |
| author_facet | Jia-feng Wang Meng-chuan Wang Lei-lei Jiang Neng-ming Lin |
| author_sort | Jia-feng Wang |
| collection | DOAJ |
| description | The involvement of nerves in the development of breast cancer has emerged as a significant factor. Interaction between the nervous system and breast cancer can influence tumor initiation, growth, invasion, metastasis, reverse resistance to drugs, promote inflammation in tumors, and impair the immune system's ability to combat cancer. This review examined the intricate relationship linking the nervous system with breast cancer, emphasizing both central and peripheral aspects of the nervous system. Moreover, we reviewed neural cell factors and their impact on breast cancer progression, alongside the interactions between nerves and immunology, microbiota in breast cancer. Furthermore, the study discussed the potential of nerves as biomarkers for diagnosing and prognosticating breast cancer, and evaluated prospects for improving chemotherapy and immunotherapy therapeutic outcomes in breast cancer treatment. We hope to provide a deeper understanding of the neurobiological underpinnings of breast cancer and pave the way for the discovery of innovative therapeutic targets and prognostic markers. |
| format | Article |
| id | doaj-art-48567d7984cc453d99ff121669783f75 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-48567d7984cc453d99ff121669783f752025-02-02T05:29:03ZengElsevierHeliyon2405-84402025-02-01113e42293The neuroscience in breast cancer: Current insights and clinical opportunitiesJia-feng Wang0Meng-chuan Wang1Lei-lei Jiang2Neng-ming Lin3Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310006, ChinaAffiliated Cixi Hospital, Wenzhou Medical University, Ningbo, 315300, ChinaThe First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei, 230031, China; Corresponding author.Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310006, China; Westlake Laboratory of Life Sciences and Biomedicine of Zhejiang Province, Hangzhou, 310024, China; Corresponding author. Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, 310006, China.The involvement of nerves in the development of breast cancer has emerged as a significant factor. Interaction between the nervous system and breast cancer can influence tumor initiation, growth, invasion, metastasis, reverse resistance to drugs, promote inflammation in tumors, and impair the immune system's ability to combat cancer. This review examined the intricate relationship linking the nervous system with breast cancer, emphasizing both central and peripheral aspects of the nervous system. Moreover, we reviewed neural cell factors and their impact on breast cancer progression, alongside the interactions between nerves and immunology, microbiota in breast cancer. Furthermore, the study discussed the potential of nerves as biomarkers for diagnosing and prognosticating breast cancer, and evaluated prospects for improving chemotherapy and immunotherapy therapeutic outcomes in breast cancer treatment. We hope to provide a deeper understanding of the neurobiological underpinnings of breast cancer and pave the way for the discovery of innovative therapeutic targets and prognostic markers.http://www.sciencedirect.com/science/article/pii/S2405844025006735Cancer neuroscienceBreast cancerInnervationCancer treatmentNeurotransmitter |
| spellingShingle | Jia-feng Wang Meng-chuan Wang Lei-lei Jiang Neng-ming Lin The neuroscience in breast cancer: Current insights and clinical opportunities Heliyon Cancer neuroscience Breast cancer Innervation Cancer treatment Neurotransmitter |
| title | The neuroscience in breast cancer: Current insights and clinical opportunities |
| title_full | The neuroscience in breast cancer: Current insights and clinical opportunities |
| title_fullStr | The neuroscience in breast cancer: Current insights and clinical opportunities |
| title_full_unstemmed | The neuroscience in breast cancer: Current insights and clinical opportunities |
| title_short | The neuroscience in breast cancer: Current insights and clinical opportunities |
| title_sort | neuroscience in breast cancer current insights and clinical opportunities |
| topic | Cancer neuroscience Breast cancer Innervation Cancer treatment Neurotransmitter |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025006735 |
| work_keys_str_mv | AT jiafengwang theneuroscienceinbreastcancercurrentinsightsandclinicalopportunities AT mengchuanwang theneuroscienceinbreastcancercurrentinsightsandclinicalopportunities AT leileijiang theneuroscienceinbreastcancercurrentinsightsandclinicalopportunities AT nengminglin theneuroscienceinbreastcancercurrentinsightsandclinicalopportunities AT jiafengwang neuroscienceinbreastcancercurrentinsightsandclinicalopportunities AT mengchuanwang neuroscienceinbreastcancercurrentinsightsandclinicalopportunities AT leileijiang neuroscienceinbreastcancercurrentinsightsandclinicalopportunities AT nengminglin neuroscienceinbreastcancercurrentinsightsandclinicalopportunities |