KSHV requires vCyclin to overcome replicative senescence in primary human lymphatic endothelial cells.
Kaposi's Sarcoma Herpesvirus (KSHV) is present in the main tumor cells of Kaposi's Sarcoma (KS), the spindle cells, which are of endothelial origin. KSHV is also associated with two B-cell lymphomas, Primary Effusion Lymphoma (PEL) and Multicentric Castleman's Disease. In KS and PEL,...
Saved in:
| Main Authors: | Terri A DiMaio, Daniel T Vogt, Michael Lagunoff |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-06-01
|
| Series: | PLoS Pathogens |
| Online Access: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008634&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi's sarcoma studies.
by: Krista Tuohinto, et al.
Published: (2023-01-01) -
Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism.
by: Zoi E Sychev, et al.
Published: (2017-03-01) -
Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis.
by: Lyndsey N Moore, et al.
Published: (2023-05-01) -
KSHV hijacks the antiviral kinase IKKε to initiate lytic replication.
by: Xiaoqian Wang, et al.
Published: (2025-01-01) -
KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia.
by: Victoria Emuss, et al.
Published: (2009-10-01)