Symptomatic, biochemical and radiographic recovery in patients with COVID-19

Symptomatic, biochemical and radiographic recovery in patients with COVID-19

Background The symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.Methods Retrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department...

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Main Authors: Onn Min Kon, Chloe I Bloom, Felicity Liew, Kartik Kumar, Clare Ross, laura Martin, Jian Chen, Jamilah Meghji, Dominic Hampson, Patrick Mallia, Brandon Wong, Victoria Pilkington, Shaan Chhabra, Ben Russell, Karthikan Srikanthan, Mirae Park, Harriet Owles, Joana Alcada, Meg Coleman, Sarah Elkin, Shweta Agrawal, Thomas Gardiner, Aaron Bell, Alice White, Gauri Vithlani, Kavina Manalan, Solange Bramer, Alejandra Martin Segura, Anushree Kucheria, Prashanthi Ratnakumar, Alexander Sheeka, Lavanya Anandan, Susan Copley, Georgina Russell
Format: Article
Language:English
Published: BMJ Publishing Group 2021-01-01
Series:BMJ Open Respiratory Research
Online Access:https://bmjopenrespres.bmj.com/content/8/1/e000908.full
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Summary:Background The symptoms, radiography, biochemistry and healthcare utilisation of patients with COVID-19 following discharge from hospital have not been well described.Methods Retrospective analysis of 401 adult patients attending a clinic following an index hospital admission or emergency department attendance with COVID-19. Regression models were used to assess the association between characteristics and persistent abnormal chest radiographs or breathlessness.Results 75.1% of patients were symptomatic at a median of 53 days post discharge and 72 days after symptom onset and chest radiographs were abnormal in 47.4%. Symptoms and radiographic abnormalities were similar in PCR-positive and PCR-negative patients. Severity of COVID-19 was significantly associated with persistent radiographic abnormalities and breathlessness. 18.5% of patients had unscheduled healthcare visits in the 30 days post discharge.Conclusions Patients with COVID-19 experience persistent symptoms and abnormal blood biomarkers with a gradual resolution of radiological abnormalities over time. These findings can inform patients and clinicians about expected recovery times and plan services for follow-up of patients with COVID-19.
ISSN:2052-4439

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