Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery
Background. Early diagnosis of anastomotic leakage (AL) after rectal surgery can reduce the adverse effects of AL, thereby reducing morbidity and mortality. Currently, there are no accepted indicators or effective scoring systems that can clearly identify patients at risk of anastomotic leakage. Met...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/9968642 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832565229231276032 |
|---|---|
| author | Jiajun Luo Hongxue Wu Yu Yang Yue Jiang Jingwen Yuan Qiang Tong |
| author_facet | Jiajun Luo Hongxue Wu Yu Yang Yue Jiang Jingwen Yuan Qiang Tong |
| author_sort | Jiajun Luo |
| collection | DOAJ |
| description | Background. Early diagnosis of anastomotic leakage (AL) after rectal surgery can reduce the adverse effects of AL, thereby reducing morbidity and mortality. Currently, there are no accepted indicators or effective scoring systems that can clearly identify patients at risk of anastomotic leakage. Methods. A prospective study with assessment of the diagnostic accuracy of oxidative stress level (CAT, SOD, MDA) in serum and drain fluid compared to white blood cell count (WBC), C-reactive protein (CRP), and neutrophil percentage (NEUT) in prediction of AL in patients undergoing elective rectal surgery with anastomosis. Results. Most of the oxidative stress indicators we detected are of considerable significance in the diagnosis of anastomotic leakage. The level of MDA on postoperative day (POD)3 (areas under the curve (AUC): 0.831) and POD5 (AUC: 0.837) in the serum and on POD3 (AUC: 0.845) in the drain fluid showed the same excellent diagnostic accuracy as the level of CRP on the POD3 (AUC: 0.847) and POD5 (AUC: 0.896). Conclusions. The overall level of oxidative stress in serum and drain fluid is a reliable indicator for the early diagnosis of anastomotic leakage after rectal surgery. More specifically, among the redox indicators analyzed, MDA has almost the same predictive value as CRP, which provides another useful biomarker for the early diagnosis of anastomotic leakage. |
| format | Article |
| id | doaj-art-4854aca808394a6d8be1fa006be77d0b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4854aca808394a6d8be1fa006be77d0b2025-02-03T01:08:48ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/99686429968642Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal SurgeryJiajun Luo0Hongxue Wu1Yu Yang2Yue Jiang3Jingwen Yuan4Qiang Tong5Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaDepartment of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaBackground. Early diagnosis of anastomotic leakage (AL) after rectal surgery can reduce the adverse effects of AL, thereby reducing morbidity and mortality. Currently, there are no accepted indicators or effective scoring systems that can clearly identify patients at risk of anastomotic leakage. Methods. A prospective study with assessment of the diagnostic accuracy of oxidative stress level (CAT, SOD, MDA) in serum and drain fluid compared to white blood cell count (WBC), C-reactive protein (CRP), and neutrophil percentage (NEUT) in prediction of AL in patients undergoing elective rectal surgery with anastomosis. Results. Most of the oxidative stress indicators we detected are of considerable significance in the diagnosis of anastomotic leakage. The level of MDA on postoperative day (POD)3 (areas under the curve (AUC): 0.831) and POD5 (AUC: 0.837) in the serum and on POD3 (AUC: 0.845) in the drain fluid showed the same excellent diagnostic accuracy as the level of CRP on the POD3 (AUC: 0.847) and POD5 (AUC: 0.896). Conclusions. The overall level of oxidative stress in serum and drain fluid is a reliable indicator for the early diagnosis of anastomotic leakage after rectal surgery. More specifically, among the redox indicators analyzed, MDA has almost the same predictive value as CRP, which provides another useful biomarker for the early diagnosis of anastomotic leakage.http://dx.doi.org/10.1155/2021/9968642 |
| spellingShingle | Jiajun Luo Hongxue Wu Yu Yang Yue Jiang Jingwen Yuan Qiang Tong Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery Mediators of Inflammation |
| title | Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery |
| title_full | Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery |
| title_fullStr | Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery |
| title_full_unstemmed | Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery |
| title_short | Oxidative Stress Level as a Predictor of Anastomotic Leakage after Rectal Surgery |
| title_sort | oxidative stress level as a predictor of anastomotic leakage after rectal surgery |
| url | http://dx.doi.org/10.1155/2021/9968642 |
| work_keys_str_mv | AT jiajunluo oxidativestresslevelasapredictorofanastomoticleakageafterrectalsurgery AT hongxuewu oxidativestresslevelasapredictorofanastomoticleakageafterrectalsurgery AT yuyang oxidativestresslevelasapredictorofanastomoticleakageafterrectalsurgery AT yuejiang oxidativestresslevelasapredictorofanastomoticleakageafterrectalsurgery AT jingwenyuan oxidativestresslevelasapredictorofanastomoticleakageafterrectalsurgery AT qiangtong oxidativestresslevelasapredictorofanastomoticleakageafterrectalsurgery |